Next-generation sequencing reveals new insights about gene usage and CDR-H3 composition in the horse antibody repertoire

•IGH predominant genes are IGHV2S3, IGHD18S1, and IGHJ1S5 in non-immunized horses.•IGL predominant genes are IGLV8S1 and IGLJ5S1 in adult non-immunized horses.•CDR-H3 composition by positions is different in horse compared to others mammals.•CDR-H3 extended form seems be predominant in horse CDR-H3...

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Veröffentlicht in:	Molecular immunology 2019-01, Vol.105, p.251-259
Hauptverfasser:	Manso, Taciana Conceição, Groenner-Penna, Michele, Minozzo, João Carlos, Antunes, Bruno Cesar, Ippolito, Gregory C., Molina, Franck, Felicori, Liza F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody repertoire CDR-H3 composition Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology Diversity Genetic Loci High-Throughput Nucleotide Sequencing Horse Horses - genetics Horses - immunology Humans Immunoglobulin Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin lambda-Chains - genetics Immunoglobulin lambda-Chains - immunology Life Sciences Mice Rabbits
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