Doxorubicin-peptide conjugates overcome multidrug resistance

A well-known mechanism leading to the emergence of multidrug-resistant tumor cells is the overexpression of P-glycoprotein (P-gp), which is capable of lowering intracellular drug concentrations. To overcome this problem, we tested the capability of two peptide vectors that are able to cross cellular...

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Veröffentlicht in:	Anti-cancer drugs 2001-02, Vol.12 (2), p.107-116
Hauptverfasser:	Mazel, Martine, Clair, Philippe, Rousselle, Christophe, Vidal, Pierre, Scherrmann, Jean-Michel, Mathieu, Danièle, Temsamani, Jamal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biochemistry, Molecular Biology Biological Transport Blood-Brain Barrier - drug effects Brain - metabolism Cell Survival - drug effects DNA, Neoplasm - biosynthesis DNA, Neoplasm - drug effects Dose-Response Relationship, Drug doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Resistance, Multiple Humans K562 Cells - drug effects K562 Cells - metabolism K562 Cells - pathology Life Sciences Mice Microscopy, Confocal Peptides - pharmacokinetics Peptides - pharmacology Verapamil - pharmacology
Online-Zugang:	Volltext
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