Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3

Combination of biophysical and structural techniques allowed characterizing and uncovering the mechanisms underlying increased binding affinity of lactosamine derivatives for galectin 3. In particular, complementing information gathered from X-ray crystallography, native mass spectrometry and isothe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-07, Vol.489 (3), p.281-286
Hauptverfasser:	Atmanene, Cédric, Ronin, Céline, Téletchéa, Stéphane, Gautier, François-Moana, Djedaïni-Pilard, Florence, Ciesielski, Fabrice, Vivat, Valérie, Grandjean, Cyrille
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Sugars - chemistry Amino Sugars - pharmacology Analytical chemistry Calorimetry Cation-π Chemical Sciences Cristallography Crystallography, X-Ray Galectin 3 - biosynthesis Galectin 3 - chemistry Galectin 3 - isolation & purification Galectin 3 - metabolism Galectin-3 inhibitor Humans Isothermal titration calorimetry Lactosamine Mass Spectrometry Medicinal Chemistry Models, Molecular Molecular Conformation Native mass spectrometry Organic chemistry Structure-Activity Relationship X-ray crystallography
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