Retrovirus-mediated transduction of primary ZAP- 70-deficient human T cells results in the selective growth advantage of gene-corrected cells : implications for gene therapy

Humans lacking the ZAP-70 protein tyrosine kinase present with an absence of CD8+ T cells and defective CD4+ T cells in the periphery. This severe combined immunodeficiency is fatal unless treated by allogeneic bone marrow transplantation. However, in the absence of suitable marrow donors, the devel...

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