Immunoglobulin lambda light chain orphons on human chromosome 8q11.2
We have identified two Vλ genes outside the major lambda locus on chromosome 22q11.2, and shown that they reside on chromosome 8q11.2. One gene (Orphéel), hybridizing strongly to the Vλ probes, was sequenced and found to belong to the Vλ8 family; the other gene (Orphée2) only hybridized weakly. Orph...
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| Veröffentlicht in: | European journal of immunology 1997-05, Vol.27 (5), p.1260-1265 |
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| container_title | European journal of immunology |
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| creator | Frippiat, Jean‐Pol Dard, Patricia Marsh, Sharon Winter, Greg Lefranc, Marie‐Paule |
| description | We have identified two Vλ genes outside the major lambda locus on chromosome 22q11.2, and shown that they reside on chromosome 8q11.2. One gene (Orphéel), hybridizing strongly to the Vλ probes, was sequenced and found to belong to the Vλ8 family; the other gene (Orphée2) only hybridized weakly. Orphée1 was present in all individuals tested (140) from three different populations, and was also found in gorillas. We envisage that these genes were generated by duplication and translocation of the Vλ8a gene (and a Vλ pseudogene) from the major locus, and that this event occurred before the evolutionary divergence of humans and gorillas. As there is no other evidence for Vλ genes outside the major locus, it appears that the human lambda locus has undergone considerably less evolutionary shuffling than either the human light chain kappa locus or the heavy chain locus. |
| doi_str_mv | 10.1002/eji.1830270530 |
| format | Article |
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One gene (Orphéel), hybridizing strongly to the Vλ probes, was sequenced and found to belong to the Vλ8 family; the other gene (Orphée2) only hybridized weakly. Orphée1 was present in all individuals tested (140) from three different populations, and was also found in gorillas. We envisage that these genes were generated by duplication and translocation of the Vλ8a gene (and a Vλ pseudogene) from the major locus, and that this event occurred before the evolutionary divergence of humans and gorillas. As there is no other evidence for Vλ genes outside the major locus, it appears that the human lambda locus has undergone considerably less evolutionary shuffling than either the human light chain kappa locus or the heavy chain locus.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830270530</identifier><identifier>PMID: 9174619</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Amino Acid Sequence ; Base Sequence ; Biochemistry, Molecular Biology ; Chromosome 8q11.2 ; Chromosomes, Human, Pair 22 ; Chromosomes, Human, Pair 8 - genetics ; Conserved Sequence - immunology ; Genes, Immunoglobulin - genetics ; Humans ; Immunoglobulin ; Immunoglobulin lambda-Chains - genetics ; Immunoglobulin Variable Region - genetics ; Life Sciences ; Molecular Sequence Data ; Multigene Family ; Orphon ; Translocation, Genetic - immunology</subject><ispartof>European journal of immunology, 1997-05, Vol.27 (5), p.1260-1265</ispartof><rights>Copyright © 1997 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4050-6489d463ced824d11e4ed0ac53587d478985132089fa6315f73c38c3c2a130a03</citedby><cites>FETCH-LOGICAL-c4050-6489d463ced824d11e4ed0ac53587d478985132089fa6315f73c38c3c2a130a03</cites><orcidid>0000-0002-4027-6269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830270530$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830270530$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9174619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02194542$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Frippiat, Jean‐Pol</creatorcontrib><creatorcontrib>Dard, Patricia</creatorcontrib><creatorcontrib>Marsh, Sharon</creatorcontrib><creatorcontrib>Winter, Greg</creatorcontrib><creatorcontrib>Lefranc, Marie‐Paule</creatorcontrib><title>Immunoglobulin lambda light chain orphons on human chromosome 8q11.2</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>We have identified two Vλ genes outside the major lambda locus on chromosome 22q11.2, and shown that they reside on chromosome 8q11.2. One gene (Orphéel), hybridizing strongly to the Vλ probes, was sequenced and found to belong to the Vλ8 family; the other gene (Orphée2) only hybridized weakly. Orphée1 was present in all individuals tested (140) from three different populations, and was also found in gorillas. We envisage that these genes were generated by duplication and translocation of the Vλ8a gene (and a Vλ pseudogene) from the major locus, and that this event occurred before the evolutionary divergence of humans and gorillas. As there is no other evidence for Vλ genes outside the major locus, it appears that the human lambda locus has undergone considerably less evolutionary shuffling than either the human light chain kappa locus or the heavy chain locus.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biochemistry, Molecular Biology</subject><subject>Chromosome 8q11.2</subject><subject>Chromosomes, Human, Pair 22</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Conserved Sequence - immunology</subject><subject>Genes, Immunoglobulin - genetics</subject><subject>Humans</subject><subject>Immunoglobulin</subject><subject>Immunoglobulin lambda-Chains - genetics</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Life Sciences</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Orphon</subject><subject>Translocation, Genetic - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1PwzAQxS0EglJY2ZAyITGk3PkjsUfEZ1ElFpgt13FJkB2XmID635OqVWFjOund796d7hFyhjBBAHrl3psJSga0BMFgj4xQUMw5ctwnIwDkOVUSjshxSu8AoAqhDsmhwpIXqEbkdhpC38Y3H-e9b9rMmzCvTOabt_ozs7UZpNgt69imLLZZ3QfTDnIXQ0wxuEx-IE7oCTlYGJ_c6baOyev93cvNYz57fpjeXM9yy0FAXnCpKl4w6ypJeYXouKvAWMGELCteSiUFMgpSLUzBUCxKZpm0zFKDDAywMbnc-NbG62XXBNOtdDSNfrye6bUGFBUXnH7hwF5s2GUXP3qXPnVoknXem9bFPulSAUNa0n9BLEDwkq23Tzag7WJKnVvsTkDQ6yz0kIX-zWIYON869_Pgqh2-ff7QV5v-d-Pd6h83ffc0_eP9AxMBkcE</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Frippiat, Jean‐Pol</creator><creator>Dard, Patricia</creator><creator>Marsh, Sharon</creator><creator>Winter, Greg</creator><creator>Lefranc, Marie‐Paule</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4027-6269</orcidid></search><sort><creationdate>199705</creationdate><title>Immunoglobulin lambda light chain orphons on human chromosome 8q11.2</title><author>Frippiat, Jean‐Pol ; Dard, Patricia ; Marsh, Sharon ; Winter, Greg ; Lefranc, Marie‐Paule</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4050-6489d463ced824d11e4ed0ac53587d478985132089fa6315f73c38c3c2a130a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biochemistry, Molecular Biology</topic><topic>Chromosome 8q11.2</topic><topic>Chromosomes, Human, Pair 22</topic><topic>Chromosomes, Human, Pair 8 - genetics</topic><topic>Conserved Sequence - immunology</topic><topic>Genes, Immunoglobulin - genetics</topic><topic>Humans</topic><topic>Immunoglobulin</topic><topic>Immunoglobulin lambda-Chains - genetics</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Life Sciences</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Orphon</topic><topic>Translocation, Genetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frippiat, Jean‐Pol</creatorcontrib><creatorcontrib>Dard, Patricia</creatorcontrib><creatorcontrib>Marsh, Sharon</creatorcontrib><creatorcontrib>Winter, Greg</creatorcontrib><creatorcontrib>Lefranc, Marie‐Paule</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frippiat, Jean‐Pol</au><au>Dard, Patricia</au><au>Marsh, Sharon</au><au>Winter, Greg</au><au>Lefranc, Marie‐Paule</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin lambda light chain orphons on human chromosome 8q11.2</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1997-05</date><risdate>1997</risdate><volume>27</volume><issue>5</issue><spage>1260</spage><epage>1265</epage><pages>1260-1265</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>We have identified two Vλ genes outside the major lambda locus on chromosome 22q11.2, and shown that they reside on chromosome 8q11.2. One gene (Orphéel), hybridizing strongly to the Vλ probes, was sequenced and found to belong to the Vλ8 family; the other gene (Orphée2) only hybridized weakly. Orphée1 was present in all individuals tested (140) from three different populations, and was also found in gorillas. We envisage that these genes were generated by duplication and translocation of the Vλ8a gene (and a Vλ pseudogene) from the major locus, and that this event occurred before the evolutionary divergence of humans and gorillas. As there is no other evidence for Vλ genes outside the major locus, it appears that the human lambda locus has undergone considerably less evolutionary shuffling than either the human light chain kappa locus or the heavy chain locus.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>9174619</pmid><doi>10.1002/eji.1830270530</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4027-6269</orcidid></addata></record> |
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| ispartof | European journal of immunology, 1997-05, Vol.27 (5), p.1260-1265 |
| issn | 0014-2980 1521-4141 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Base Sequence Biochemistry, Molecular Biology Chromosome 8q11.2 Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 8 - genetics Conserved Sequence - immunology Genes, Immunoglobulin - genetics Humans Immunoglobulin Immunoglobulin lambda-Chains - genetics Immunoglobulin Variable Region - genetics Life Sciences Molecular Sequence Data Multigene Family Orphon Translocation, Genetic - immunology |
| title | Immunoglobulin lambda light chain orphons on human chromosome 8q11.2 |
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