CAV-2 — why a canine virus is a neurobiologist's best friend

Highlights • CAV-2 vectors preferentially transduce neurons in rodents and primates. • Retrograde axonal transport leads to widespread biodistribution in the brain parenchyma. • Helper-dependent CAV-2 vector treat global brain pathology in MPS brain. • Use of CAV-2 vector for fundamental neurobiolog...

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Veröffentlicht in:	Current opinion in pharmacology 2015-10, Vol.24, p.86-93
Hauptverfasser:	Junyent, Felix, Kremer, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Canine - genetics Animals Biochemistry, Molecular Biology Genetic Therapy Genetic Vectors Humans Internal Medicine Life Sciences Medical Education Neurodegenerative Diseases - therapy Neurons - metabolism
Online-Zugang:	Volltext
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