Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC lineage specification and commitment. Here, we show that the commitment of human and murine HSCs to the erythroid lineag...

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Veröffentlicht in:	Cell stem cell 2014-08, Vol.15 (2), p.169-184
Hauptverfasser:	Oburoglu, Leal, Tardito, Saverio, Fritz, Vanessa, de Barros, Stéphanie C., Merida, Peggy, Craveiro, Marco, Mamede, João, Cretenet, Gaspard, Mongellaz, Cédric, An, Xiuli, Klysz, Dorota, Touhami, Jawida, Boyer-Clavel, Myriam, Battini, Jean-Luc, Dardalhon, Valérie, Zimmermann, Valérie S., Mohandas, Narla, Gottlieb, Eyal, Sitbon, Marc, Kinet, Sandrina, Taylor, Naomi
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - metabolism Amino Acid Transport System ASC - metabolism Animals Antigens, CD34 - metabolism Biochemistry, Molecular Biology Biological Transport Cell Differentiation Cell Lineage Chromatography, Liquid Erythrocytes - cytology Gene Expression Regulation Glucose - metabolism Glutamine - metabolism Glycolysis Green Fluorescent Proteins - metabolism Hematopoietic Stem Cells - cytology Humans Life Sciences Mass Spectrometry Mice Mice, Inbred C57BL Minor Histocompatibility Antigens RNA, Small Interfering - metabolism
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