Mutagenicity and genotoxicity of PM2.5 issued from an urbano-industrialized area of Dunkerque (France)

Epidemiological studies have demonstrated the link between chronic exposure to particulate matter (PM), especially particles with an aerodynamic diameter lesser than 2.5 µm (PM2.5), and lung cancer. Mechanistic investigations focus on the contribution of the various genotoxicants adsorbed onto the p...

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Veröffentlicht in:	Journal of applied toxicology 2011-03, Vol.31 (2), p.131-138
Hauptverfasser:	André, V., Billet, S., Pottier, D., Le Goff, J., Pottier, I., Garçon, G., Shirali, P., Sichel, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-OHdG A549 cells Air air pollution Ames test Biological and medical sciences Carcinogenicity Tests Carcinogens Carcinogens - chemistry Carcinogens - toxicity Cell Line Cells, Cultured Chemical mutagenesis Deoxyguanosine Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA Adducts DNA Adducts - metabolism DNA bulky adducts Environmental pollutants toxicology France genotoxicity human alveolar macrophages Humans Industry Life Sciences Macrophages, Alveolar Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Medical sciences mutagenicity Mutagenicity Tests Mutagens Mutagens - chemistry Mutagens - toxicity Osmolar Concentration Particle Size Particulate Matter Particulate Matter - chemistry Particulate Matter - toxicity PM2.5 Salmonella Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - metabolism Species Specificity Time Factors Toxicology Urbanization
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