Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability Positive Selection Pressure Mutational Background Negative Selection Pressure Mutational Frequency Microsatellite length (bp)

Background & Aims: Recent studies have shown that cancers arise as a result of the positive selection of driver somatic events in tumor DNA, with negative selection playing only a minor role, if any. However, these investigations were concerned with alterations at nonrepetitive sequences and did...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2018, Vol.6 (3), p.277-300
Hauptverfasser:	Jonchère, Vincent, Marisa, Laetitia, Greene, Malorie, Virouleau, Alain, Buhard, Olivier, Bertrand, Romane, Svrcek, Magali, Cervera, Pascale, Goloudina, Anastasia, Guillerm, Erell, Coulet, Florence, Landman, Samuel, Ratovomanana, Toky, Job, Sylvie, Ayadi, Mira, Elarouci, Nabila, Armenoult, Lucile, Merabtene, Fatiha, Dumont, Sylvie, Parc, Yann, Lefèvre, Jérémie, André, Thierry, Fléjou, Jean-François, Guilloux, Agathe, Collura, Ada, de Reynies, Aurélien, Duval, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Genetics Human genetics Human health and pathology Hépatology and Gastroenterology Life Sciences
Online-Zugang:	Volltext
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