Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection

Host cell proteases are involved in influenza pathogenesis. We examined the role of tissue kallikrein 1 (KLK1) by comparing wild-type (WT) and KLK1-deficient mice infected with influenza H3N2 virus. The levels of KLK1 in lung tissue and in bronchoalveolar lavage (BAL) fluid increased substantially d...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2019-06, Vol.316 (6), p.L1127-L1140
Hauptverfasser:	Magnen, Melia, Gueugnon, Fabien, Petit-Courty, Agnès, Baranek, Thomas, Sizaret, Damien, Brewah, Yambasu A, Humbles, Alison A, Si-Tahar, Mustapha, Courty, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acute Lung Injury - pathology Acute Lung Injury - virology Alveoli Animals Antiviral activity Apoptosis Apoptosis - physiology Bronchus CCL3 protein Cell Line Cellular Biology Chemokine CCL2 - metabolism Chemokine CCL3 - metabolism Chemokine CCL5 - metabolism Chemokine CXCL10 - metabolism Chemokines Chronic infection Chronic obstructive pulmonary disease Colony-stimulating factor CXCL10 protein Depletion Dogs Epithelial cells Granulocyte-macrophage colony stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - analysis Humans Infections Infectivity Influenza Influenza A Virus, H3N2 Subtype Kallikrein Killer Cells, Natural - immunology KLK1 gene Life Sciences Lung diseases Macrophages Macrophages, Alveolar - pathology Madin Darby Canine Kidney Cells Mice Mice, Inbred C57BL Mice, Knockout Microbiology and Parasitology Monoclonal antibodies Monocyte chemoattractant protein 1 mRNA Natural killer cells Obstructive lung disease Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Pathogenesis Pathogens Phenotypes Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - virology Respiratory Mucosa - metabolism Rodents Tissue Kallikreins - antagonists & inhibitors Tissue Kallikreins - genetics Tissue Kallikreins - metabolism Tissues Trypsin Viral infections Viruses
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