High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome

Background PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the PTEN tumour suppressor gene, including Cowden syndrome which is characterised by an increased risk of breast and thyroid cancers. Because PHTS is rare, data regarding cancer risks a...

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Veröffentlicht in:	Journal of medical genetics 2013-04, Vol.50 (4), p.255-263
Hauptverfasser:	Bubien, Virginie, Bonnet, Françoise, Brouste, Veronique, Hoppe, Stéphanie, Barouk-Simonet, Emmanuelle, David, Albert, Edery, Patrick, Bottani, Armand, Layet, Valérie, Caron, Olivier, Gilbert-Dussardier, Brigitte, Delnatte, Capucine, Dugast, Catherine, Fricker, Jean-Pierre, Bonneau, Dominique, Sevenet, Nicolas, Longy, Michel, Caux, Frédéric, Abramowicz, Marc, Bessis, Didier, Bieth, Eric, Bérard, Valérie Bonadonaon, Bonnetblanc, Jean-Marie, Demange, Liliane, Feillet, François, Frebourg, Thierry, Giraud, Sophie, Giurgea, Irina, Heron, Delphine, Holder, Muriel, Journel, Hubert, Julia, Sophie, Kacem, Maha, Lejeune, Sophie, Leprat, Frédéric, Leroux, Dominique, Lok, Catherine, Lortholary, Alain, Lyonnet, Stanislas, Margueritte, Geneviève, Mauillon, Jacques, Mazereeuw-Hautier, Juliette, Odent, Sylvie, Penet, Clotilde, Philippe, Anne, Plauchu, Henri, Plessismenceau, Ghislaine, Plouvieron, Emmanuel, Richard, Marie-Aleth, Saadi, Abdelkrim, Saurin, Jean-Christophe, Tinat, Julie, Vabres, Pierre, Van Maldergemteil, Lionel, Vennin, Philippe, Weiller, Pierre-Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Breast Neoplasms - etiology Breast Neoplasms - genetics Cancer Cancer genetics Cancer: Breast Clinical Genetics Endometrial Neoplasms - genetics Female Genetic Association Studies Genetic testing Genotype & phenotype Germ-Line Mutation Guidelines Hamartoma Syndrome, Multiple - complications Hamartoma Syndrome, Multiple - genetics Hamartoma Syndrome, Multiple - pathology Humans Life Sciences Male Medical diagnosis Melanoma - etiology Melanoma - genetics Middle Aged Molecular Genetics Mutation Phosphatase PTEN Phosphohydrolase - genetics Questionnaires Risk Factors Survival analysis Thyroid Disease Thyroid gland Thyroid Neoplasms - etiology Thyroid Neoplasms - genetics
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