Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA proj...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2011-07, Vol.333 (6038), p.104-107 |
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| creator | Viviani, Daniele Charlet, Alexandre van den Burg, Erwin Robinet, Camille Hurni, Nicolas Abatis, Marios Magara, Fulvio Stoop, Ron |
| description | Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response. |
| doi_str_mv | 10.1126/science.1201043 |
| format | Article |
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We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1201043</identifier><identifier>PMID: 21719680</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Amygdala ; Amygdala - physiology ; Animal behavior ; Animals ; Behavioral neuroscience ; Behavioral psychophysiology ; Biological and medical sciences ; Bombesin - pharmacology ; Brain research ; Brain stem ; Brain Stem - physiology ; Cognitive science ; Conditioning (Psychology) ; Electrophysiology ; Fear ; Fear - physiology ; Feedback (Response) ; Female ; Freezing ; Fundamental and applied biological sciences. Psychology ; GABA-A Receptor Agonists - pharmacology ; Heart rate ; Heart Rate - drug effects ; Hormones and behavior ; Hypothalamus - physiology ; Injections ; Life Sciences ; Male ; Muscimol - pharmacology ; Neural Inhibition ; Neural Pathways - physiology ; Neurology ; Neurons ; Neurons - physiology ; Neurons and Cognition ; Neuroscience ; Oxytocin - agonists ; Oxytocin - analogs & derivatives ; Oxytocin - pharmacology ; Oxytocin - physiology ; Patch-Clamp Techniques ; Periaqueductal Gray - physiology ; Physiological psychology ; Physiological regulation ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Science (American Association for the Advancement of Science), 2011-07, Vol.333 (6038), p.104-107</ispartof><rights>Copyright © 2011 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Association for the Advancement of Science</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-9cc96b0bb36eddd8d8a5abf5b48589bb30ec0c9707cff90baadcaa62486dd96d3</citedby><cites>FETCH-LOGICAL-c507t-9cc96b0bb36eddd8d8a5abf5b48589bb30ec0c9707cff90baadcaa62486dd96d3</cites><orcidid>0000-0003-4837-3706</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27978158$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27978158$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24327744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21719680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02166043$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Viviani, Daniele</creatorcontrib><creatorcontrib>Charlet, Alexandre</creatorcontrib><creatorcontrib>van den Burg, Erwin</creatorcontrib><creatorcontrib>Robinet, Camille</creatorcontrib><creatorcontrib>Hurni, Nicolas</creatorcontrib><creatorcontrib>Abatis, Marios</creatorcontrib><creatorcontrib>Magara, Fulvio</creatorcontrib><creatorcontrib>Stoop, Ron</creatorcontrib><title>Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.</description><subject>Amygdala</subject><subject>Amygdala - physiology</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavioral neuroscience</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Bombesin - pharmacology</subject><subject>Brain research</subject><subject>Brain stem</subject><subject>Brain Stem - physiology</subject><subject>Cognitive science</subject><subject>Conditioning (Psychology)</subject><subject>Electrophysiology</subject><subject>Fear</subject><subject>Fear - physiology</subject><subject>Feedback (Response)</subject><subject>Female</subject><subject>Freezing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA-A Receptor Agonists - pharmacology</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Hormones and behavior</subject><subject>Hypothalamus - physiology</subject><subject>Injections</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Muscimol - pharmacology</subject><subject>Neural Inhibition</subject><subject>Neural Pathways - physiology</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neurons and Cognition</subject><subject>Neuroscience</subject><subject>Oxytocin - agonists</subject><subject>Oxytocin - analogs & derivatives</subject><subject>Oxytocin - pharmacology</subject><subject>Oxytocin - physiology</subject><subject>Patch-Clamp Techniques</subject><subject>Periaqueductal Gray - physiology</subject><subject>Physiological psychology</subject><subject>Physiological regulation</subject><subject>Psychology. Psychoanalysis. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2011-07, Vol.333 (6038), p.104-107 |
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| subjects | Amygdala Amygdala - physiology Animal behavior Animals Behavioral neuroscience Behavioral psychophysiology Biological and medical sciences Bombesin - pharmacology Brain research Brain stem Brain Stem - physiology Cognitive science Conditioning (Psychology) Electrophysiology Fear Fear - physiology Feedback (Response) Female Freezing Fundamental and applied biological sciences. Psychology GABA-A Receptor Agonists - pharmacology Heart rate Heart Rate - drug effects Hormones and behavior Hypothalamus - physiology Injections Life Sciences Male Muscimol - pharmacology Neural Inhibition Neural Pathways - physiology Neurology Neurons Neurons - physiology Neurons and Cognition Neuroscience Oxytocin - agonists Oxytocin - analogs & derivatives Oxytocin - pharmacology Oxytocin - physiology Patch-Clamp Techniques Periaqueductal Gray - physiology Physiological psychology Physiological regulation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley |
| title | Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala |
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