Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma

Alginate‐encapsulated HepG2 cells cultured in microgravity have the potential to serve as the cellular component of a bioartificial liver. This study investigates their performance in normal and liver failure (LF) human plasma over 6–8 h in a fluidized bed bioreactor. After 8 days of microgravity cu...

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Veröffentlicht in:	Artificial organs 2009-12, Vol.33 (12), p.1117-1126
Hauptverfasser:	Coward, Sam M., Legallais, Cécile, David, Bertrand, Thomas, Michael, Foo, Ying, Mavri-Damelin, Demetra, Hodgson, Humphrey J., Selden, Clare
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Alginates - chemistry Ammonia - metabolism Artificial liver Bilirubin - metabolism Bioengineering Bioreactors Cell Survival Cell- and Tissue-Based Therapy - methods Cells, Immobilized - cytology Cells, Immobilized - metabolism Engineering Sciences Glucose - metabolism Glucuronic Acid - chemistry Hep G2 Cells - cytology Hep G2 Cells - metabolism Hepatocytes Hexuronic Acids - chemistry Humans L-Lactate Dehydrogenase - metabolism Life Sciences Liver failure Liver Failure - therapy Liver, Artificial Mechanics Mechanics of materials Physics Plasma Plasma - metabolism Transaminases - metabolism Tumor cell line
Online-Zugang:	Volltext
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