Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis

•In the CNS, JAM-B expression is restricted to endothelial cells.•JAM-B is not required for BBB integrity at the level of tight junctions.•Absence of JAM-B ameliorates clinical signs of actively induced EAE.•JAM-B is not expressed on mouse myeloid cells.•During EAE, lack of JAM-B results in immune c...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2018-10, Vol.73, p.3-20
Hauptverfasser:	Tietz, Silvia, Périnat, Therese, Greene, Gretchen, Enzmann, Gaby, Deutsch, Urban, Adams, Ralf, Imhof, Beat, Aurrand-Lions, Michel, Engelhardt, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-brain barrier Blood-Brain Barrier - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Movement - physiology Central Nervous System - metabolism Central Nervous System - physiology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - physiopathology Endothelium, Vascular - metabolism Experimental autoimmune encephalomyelitis Female Gelatinases Glia limitans Integrin alpha4beta1 - metabolism Junctional Adhesion Molecule B - genetics Junctional Adhesion Molecule B - metabolism Junctional Adhesion Molecule B - physiology Junctional adhesion molecules Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Multiple Sclerosis - metabolism Multiple Sclerosis - physiopathology Myelin-Oligodendrocyte Glycoprotein - pharmacology Myeloid Cells - metabolism Myeloid Cells - physiology Tight junctions Tight Junctions - metabolism
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