Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)

This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Digestive and liver disease 2018-12, Vol.50 (12), p.1257-1271
Hauptverfasser: Neuzillet, Cindy, Gaujoux, Sébastien, Williet, Nicolas, Bachet, Jean-Baptiste, Bauguion, Lucile, Colson Durand, Laurianne, Conroy, Thierry, Dahan, Laetitia, Gilabert, Marine, Huguet, Florence, Marthey, Lysiane, Meilleroux, Julie, de Mestier, Louis, Napoléon, Bertrand, Portales, Fabienne, Sa Cunha, Antonio, Schwarz, Lilian, Taieb, Julien, Chibaudel, Benoist, Bouché, Olivier, Hammel, Pascal
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1271
container_issue 12
container_start_page 1257
container_title Digestive and liver disease
container_volume 50
creator Neuzillet, Cindy
Gaujoux, Sébastien
Williet, Nicolas
Bachet, Jean-Baptiste
Bauguion, Lucile
Colson Durand, Laurianne
Conroy, Thierry
Dahan, Laetitia
Gilabert, Marine
Huguet, Florence
Marthey, Lysiane
Meilleroux, Julie
de Mestier, Louis
Napoléon, Bertrand
Portales, Fabienne
Sa Cunha, Antonio
Schwarz, Lilian
Taieb, Julien
Chibaudel, Benoist
Bouché, Olivier
Hammel, Pascal
description This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the previous guidelines, recent literature review and expert opinions. Recommendations were graded in three categories, according to the level of evidence. Over the last seven years, significant changes in PA management have been implemented in clinical practice. Imaging/staging: diffusion magnetic resonance imaging is useful before surgery to rule out small liver metastases. Surgery: centralization of pancreatic surgery in expert centers is associated with a decreased postoperative mortality. Adjuvant chemotherapy: modified FOLFIRINOX in fit patients, or gemcitabine, or 5-FU, or gemcitabine plus capecitabine, to be discussed on a case-by-case basis. Locally advanced PA: no survival benefit of chemoradiotherapy. Metastatic PA: FOLFIRINOX and gemcitabine plus nab-paclitaxel combination are first-line standards in fit patients; second-line with 5FU/nal-IRI or 5FU/oxaliplatin combination after first-line gemcitabine. Guidelines for management of PA are continuously evolving and need to be regularly updated. This constant progress is made possible through clinical and translational research. However, as each individual case is particular, they cannot substitute to multidisciplinary tumor board discussion.
doi_str_mv 10.1016/j.dld.2018.08.008
format Article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02143547v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1590865818308880</els_id><sourcerecordid>2108251526</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-cb68f2fe5f6d7da44f321832b12d76ae5db166b75baab91a02e14b2495f89d323</originalsourceid><addsrcrecordid>eNp9UUFu2zAQFIoWTZr2Ab0UPCaA5JKUSNHNyVUku4BhF3ZyJihyldCQJZeUUuQvfWzpOM2xwGJ3sDM7h50o-kzwhGDCv-4mpjUTiomY4FBYvInOichFkjJO3wbMpjgRnImz6IP3O4wp4Qy_j87SgKY8x-fRn5-q0w7UYDXSAYL7hioHnX5AurWd1apFB6d04AHdj9ZA2IJHTe-Qseq-6731MRqOFnvoBqQ6E8i27X8n4wFdblfVvIxRVRU3MZqXm2K9idHd6kcxWxVlgNtnYluVz32zjtGsWHy_DaMqrj5G7xrVevj0Mi-iu6q8LRbJcj0PDstEpyIfEl1z0dAGWMNNblSWNSklIqU1oSbnCpipCed1zmql6ilRmALJappNWSOmJqXpRXR18n1QrTw4u1fuSfbKysVsKY-78K4sZVn-SIL28qQ9uP7XCH6Qe-s1tK3qoB-9pAQLygijPEjJSapd772D5tWbYHkMUO5kCFAeA5Q4FBbh5suL_Vjvwbxe_EssCK5PAggPebTgpNc25AXGOtCDNL39j_1fUxelvw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108251526</pqid></control><display><type>article</type><title>Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Neuzillet, Cindy ; Gaujoux, Sébastien ; Williet, Nicolas ; Bachet, Jean-Baptiste ; Bauguion, Lucile ; Colson Durand, Laurianne ; Conroy, Thierry ; Dahan, Laetitia ; Gilabert, Marine ; Huguet, Florence ; Marthey, Lysiane ; Meilleroux, Julie ; de Mestier, Louis ; Napoléon, Bertrand ; Portales, Fabienne ; Sa Cunha, Antonio ; Schwarz, Lilian ; Taieb, Julien ; Chibaudel, Benoist ; Bouché, Olivier ; Hammel, Pascal</creator><creatorcontrib>Neuzillet, Cindy ; Gaujoux, Sébastien ; Williet, Nicolas ; Bachet, Jean-Baptiste ; Bauguion, Lucile ; Colson Durand, Laurianne ; Conroy, Thierry ; Dahan, Laetitia ; Gilabert, Marine ; Huguet, Florence ; Marthey, Lysiane ; Meilleroux, Julie ; de Mestier, Louis ; Napoléon, Bertrand ; Portales, Fabienne ; Sa Cunha, Antonio ; Schwarz, Lilian ; Taieb, Julien ; Chibaudel, Benoist ; Bouché, Olivier ; Hammel, Pascal ; on behalf of the Thésaurus National de Cancérologie Digestive (TNCD) ; Société Française d’Endoscopie Digestive (SFED) ; Fédération Francophone de Cancérologie Digestive (FFCD) ; Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR) ; Association Française de Chirurgie (AFC) ; Société Française de Radiothérapie Oncologique (SFRO) ; Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER) ; Société Française de Chirurgie Digestive (SFCD) ; Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation (ACHBT) ; Société Nationale Française de Gastroentérologie (SNFGE) ; Thésaurus National de Cancérologie Digestive (TNCD)</creatorcontrib><description>This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the previous guidelines, recent literature review and expert opinions. Recommendations were graded in three categories, according to the level of evidence. Over the last seven years, significant changes in PA management have been implemented in clinical practice. Imaging/staging: diffusion magnetic resonance imaging is useful before surgery to rule out small liver metastases. Surgery: centralization of pancreatic surgery in expert centers is associated with a decreased postoperative mortality. Adjuvant chemotherapy: modified FOLFIRINOX in fit patients, or gemcitabine, or 5-FU, or gemcitabine plus capecitabine, to be discussed on a case-by-case basis. Locally advanced PA: no survival benefit of chemoradiotherapy. Metastatic PA: FOLFIRINOX and gemcitabine plus nab-paclitaxel combination are first-line standards in fit patients; second-line with 5FU/nal-IRI or 5FU/oxaliplatin combination after first-line gemcitabine. Guidelines for management of PA are continuously evolving and need to be regularly updated. This constant progress is made possible through clinical and translational research. However, as each individual case is particular, they cannot substitute to multidisciplinary tumor board discussion.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2018.08.008</identifier><identifier>PMID: 30219670</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Antineoplastic Combined Chemotherapy Protocols ; Chemotherapy ; France ; French intergroup clinical practice guidelines ; Humans ; Life Sciences ; Pancreatic adenocarcinoma ; Pancreatic Neoplasms ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - therapy ; Practice Guidelines as Topic ; Prognosis ; Radiotherapy ; Societies, Medical ; Surgery ; Surgical Procedures, Operative</subject><ispartof>Digestive and liver disease, 2018-12, Vol.50 (12), p.1257-1271</ispartof><rights>2018 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-cb68f2fe5f6d7da44f321832b12d76ae5db166b75baab91a02e14b2495f89d323</citedby><cites>FETCH-LOGICAL-c387t-cb68f2fe5f6d7da44f321832b12d76ae5db166b75baab91a02e14b2495f89d323</cites><orcidid>0000-0001-9715-9189 ; 0000-0001-7037-7477 ; 0000-0001-7548-284X ; 0000-0002-9955-4753 ; 0000-0002-7296-5464 ; 0000-0003-4015-5368 ; 0000-0003-1868-3260</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2018.08.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30219670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-02143547$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Neuzillet, Cindy</creatorcontrib><creatorcontrib>Gaujoux, Sébastien</creatorcontrib><creatorcontrib>Williet, Nicolas</creatorcontrib><creatorcontrib>Bachet, Jean-Baptiste</creatorcontrib><creatorcontrib>Bauguion, Lucile</creatorcontrib><creatorcontrib>Colson Durand, Laurianne</creatorcontrib><creatorcontrib>Conroy, Thierry</creatorcontrib><creatorcontrib>Dahan, Laetitia</creatorcontrib><creatorcontrib>Gilabert, Marine</creatorcontrib><creatorcontrib>Huguet, Florence</creatorcontrib><creatorcontrib>Marthey, Lysiane</creatorcontrib><creatorcontrib>Meilleroux, Julie</creatorcontrib><creatorcontrib>de Mestier, Louis</creatorcontrib><creatorcontrib>Napoléon, Bertrand</creatorcontrib><creatorcontrib>Portales, Fabienne</creatorcontrib><creatorcontrib>Sa Cunha, Antonio</creatorcontrib><creatorcontrib>Schwarz, Lilian</creatorcontrib><creatorcontrib>Taieb, Julien</creatorcontrib><creatorcontrib>Chibaudel, Benoist</creatorcontrib><creatorcontrib>Bouché, Olivier</creatorcontrib><creatorcontrib>Hammel, Pascal</creatorcontrib><creatorcontrib>on behalf of the Thésaurus National de Cancérologie Digestive (TNCD)</creatorcontrib><creatorcontrib>Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><creatorcontrib>Fédération Francophone de Cancérologie Digestive (FFCD)</creatorcontrib><creatorcontrib>Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR)</creatorcontrib><creatorcontrib>Association Française de Chirurgie (AFC)</creatorcontrib><creatorcontrib>Société Française de Radiothérapie Oncologique (SFRO)</creatorcontrib><creatorcontrib>Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER)</creatorcontrib><creatorcontrib>Société Française de Chirurgie Digestive (SFCD)</creatorcontrib><creatorcontrib>Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation (ACHBT)</creatorcontrib><creatorcontrib>Société Nationale Française de Gastroentérologie (SNFGE)</creatorcontrib><creatorcontrib>Thésaurus National de Cancérologie Digestive (TNCD)</creatorcontrib><title>Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the previous guidelines, recent literature review and expert opinions. Recommendations were graded in three categories, according to the level of evidence. Over the last seven years, significant changes in PA management have been implemented in clinical practice. Imaging/staging: diffusion magnetic resonance imaging is useful before surgery to rule out small liver metastases. Surgery: centralization of pancreatic surgery in expert centers is associated with a decreased postoperative mortality. Adjuvant chemotherapy: modified FOLFIRINOX in fit patients, or gemcitabine, or 5-FU, or gemcitabine plus capecitabine, to be discussed on a case-by-case basis. Locally advanced PA: no survival benefit of chemoradiotherapy. Metastatic PA: FOLFIRINOX and gemcitabine plus nab-paclitaxel combination are first-line standards in fit patients; second-line with 5FU/nal-IRI or 5FU/oxaliplatin combination after first-line gemcitabine. Guidelines for management of PA are continuously evolving and need to be regularly updated. This constant progress is made possible through clinical and translational research. However, as each individual case is particular, they cannot substitute to multidisciplinary tumor board discussion.</description><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Chemotherapy</subject><subject>France</subject><subject>French intergroup clinical practice guidelines</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Pancreatic adenocarcinoma</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Practice Guidelines as Topic</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>Societies, Medical</subject><subject>Surgery</subject><subject>Surgical Procedures, Operative</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UUFu2zAQFIoWTZr2Ab0UPCaA5JKUSNHNyVUku4BhF3ZyJihyldCQJZeUUuQvfWzpOM2xwGJ3sDM7h50o-kzwhGDCv-4mpjUTiomY4FBYvInOichFkjJO3wbMpjgRnImz6IP3O4wp4Qy_j87SgKY8x-fRn5-q0w7UYDXSAYL7hioHnX5AurWd1apFB6d04AHdj9ZA2IJHTe-Qseq-6731MRqOFnvoBqQ6E8i27X8n4wFdblfVvIxRVRU3MZqXm2K9idHd6kcxWxVlgNtnYluVz32zjtGsWHy_DaMqrj5G7xrVevj0Mi-iu6q8LRbJcj0PDstEpyIfEl1z0dAGWMNNblSWNSklIqU1oSbnCpipCed1zmql6ilRmALJappNWSOmJqXpRXR18n1QrTw4u1fuSfbKysVsKY-78K4sZVn-SIL28qQ9uP7XCH6Qe-s1tK3qoB-9pAQLygijPEjJSapd772D5tWbYHkMUO5kCFAeA5Q4FBbh5suL_Vjvwbxe_EssCK5PAggPebTgpNc25AXGOtCDNL39j_1fUxelvw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Neuzillet, Cindy</creator><creator>Gaujoux, Sébastien</creator><creator>Williet, Nicolas</creator><creator>Bachet, Jean-Baptiste</creator><creator>Bauguion, Lucile</creator><creator>Colson Durand, Laurianne</creator><creator>Conroy, Thierry</creator><creator>Dahan, Laetitia</creator><creator>Gilabert, Marine</creator><creator>Huguet, Florence</creator><creator>Marthey, Lysiane</creator><creator>Meilleroux, Julie</creator><creator>de Mestier, Louis</creator><creator>Napoléon, Bertrand</creator><creator>Portales, Fabienne</creator><creator>Sa Cunha, Antonio</creator><creator>Schwarz, Lilian</creator><creator>Taieb, Julien</creator><creator>Chibaudel, Benoist</creator><creator>Bouché, Olivier</creator><creator>Hammel, Pascal</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9715-9189</orcidid><orcidid>https://orcid.org/0000-0001-7037-7477</orcidid><orcidid>https://orcid.org/0000-0001-7548-284X</orcidid><orcidid>https://orcid.org/0000-0002-9955-4753</orcidid><orcidid>https://orcid.org/0000-0002-7296-5464</orcidid><orcidid>https://orcid.org/0000-0003-4015-5368</orcidid><orcidid>https://orcid.org/0000-0003-1868-3260</orcidid></search><sort><creationdate>20181201</creationdate><title>Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)</title><author>Neuzillet, Cindy ; Gaujoux, Sébastien ; Williet, Nicolas ; Bachet, Jean-Baptiste ; Bauguion, Lucile ; Colson Durand, Laurianne ; Conroy, Thierry ; Dahan, Laetitia ; Gilabert, Marine ; Huguet, Florence ; Marthey, Lysiane ; Meilleroux, Julie ; de Mestier, Louis ; Napoléon, Bertrand ; Portales, Fabienne ; Sa Cunha, Antonio ; Schwarz, Lilian ; Taieb, Julien ; Chibaudel, Benoist ; Bouché, Olivier ; Hammel, Pascal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-cb68f2fe5f6d7da44f321832b12d76ae5db166b75baab91a02e14b2495f89d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Chemotherapy</topic><topic>France</topic><topic>French intergroup clinical practice guidelines</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Pancreatic adenocarcinoma</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Practice Guidelines as Topic</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>Societies, Medical</topic><topic>Surgery</topic><topic>Surgical Procedures, Operative</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuzillet, Cindy</creatorcontrib><creatorcontrib>Gaujoux, Sébastien</creatorcontrib><creatorcontrib>Williet, Nicolas</creatorcontrib><creatorcontrib>Bachet, Jean-Baptiste</creatorcontrib><creatorcontrib>Bauguion, Lucile</creatorcontrib><creatorcontrib>Colson Durand, Laurianne</creatorcontrib><creatorcontrib>Conroy, Thierry</creatorcontrib><creatorcontrib>Dahan, Laetitia</creatorcontrib><creatorcontrib>Gilabert, Marine</creatorcontrib><creatorcontrib>Huguet, Florence</creatorcontrib><creatorcontrib>Marthey, Lysiane</creatorcontrib><creatorcontrib>Meilleroux, Julie</creatorcontrib><creatorcontrib>de Mestier, Louis</creatorcontrib><creatorcontrib>Napoléon, Bertrand</creatorcontrib><creatorcontrib>Portales, Fabienne</creatorcontrib><creatorcontrib>Sa Cunha, Antonio</creatorcontrib><creatorcontrib>Schwarz, Lilian</creatorcontrib><creatorcontrib>Taieb, Julien</creatorcontrib><creatorcontrib>Chibaudel, Benoist</creatorcontrib><creatorcontrib>Bouché, Olivier</creatorcontrib><creatorcontrib>Hammel, Pascal</creatorcontrib><creatorcontrib>on behalf of the Thésaurus National de Cancérologie Digestive (TNCD)</creatorcontrib><creatorcontrib>Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><creatorcontrib>Fédération Francophone de Cancérologie Digestive (FFCD)</creatorcontrib><creatorcontrib>Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR)</creatorcontrib><creatorcontrib>Association Française de Chirurgie (AFC)</creatorcontrib><creatorcontrib>Société Française de Radiothérapie Oncologique (SFRO)</creatorcontrib><creatorcontrib>Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER)</creatorcontrib><creatorcontrib>Société Française de Chirurgie Digestive (SFCD)</creatorcontrib><creatorcontrib>Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation (ACHBT)</creatorcontrib><creatorcontrib>Société Nationale Française de Gastroentérologie (SNFGE)</creatorcontrib><creatorcontrib>Thésaurus National de Cancérologie Digestive (TNCD)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuzillet, Cindy</au><au>Gaujoux, Sébastien</au><au>Williet, Nicolas</au><au>Bachet, Jean-Baptiste</au><au>Bauguion, Lucile</au><au>Colson Durand, Laurianne</au><au>Conroy, Thierry</au><au>Dahan, Laetitia</au><au>Gilabert, Marine</au><au>Huguet, Florence</au><au>Marthey, Lysiane</au><au>Meilleroux, Julie</au><au>de Mestier, Louis</au><au>Napoléon, Bertrand</au><au>Portales, Fabienne</au><au>Sa Cunha, Antonio</au><au>Schwarz, Lilian</au><au>Taieb, Julien</au><au>Chibaudel, Benoist</au><au>Bouché, Olivier</au><au>Hammel, Pascal</au><aucorp>on behalf of the Thésaurus National de Cancérologie Digestive (TNCD)</aucorp><aucorp>Société Française d’Endoscopie Digestive (SFED)</aucorp><aucorp>Fédération Francophone de Cancérologie Digestive (FFCD)</aucorp><aucorp>Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR)</aucorp><aucorp>Association Française de Chirurgie (AFC)</aucorp><aucorp>Société Française de Radiothérapie Oncologique (SFRO)</aucorp><aucorp>Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER)</aucorp><aucorp>Société Française de Chirurgie Digestive (SFCD)</aucorp><aucorp>Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation (ACHBT)</aucorp><aucorp>Société Nationale Française de Gastroentérologie (SNFGE)</aucorp><aucorp>Thésaurus National de Cancérologie Digestive (TNCD)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>50</volume><issue>12</issue><spage>1257</spage><epage>1271</epage><pages>1257-1271</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the previous guidelines, recent literature review and expert opinions. Recommendations were graded in three categories, according to the level of evidence. Over the last seven years, significant changes in PA management have been implemented in clinical practice. Imaging/staging: diffusion magnetic resonance imaging is useful before surgery to rule out small liver metastases. Surgery: centralization of pancreatic surgery in expert centers is associated with a decreased postoperative mortality. Adjuvant chemotherapy: modified FOLFIRINOX in fit patients, or gemcitabine, or 5-FU, or gemcitabine plus capecitabine, to be discussed on a case-by-case basis. Locally advanced PA: no survival benefit of chemoradiotherapy. Metastatic PA: FOLFIRINOX and gemcitabine plus nab-paclitaxel combination are first-line standards in fit patients; second-line with 5FU/nal-IRI or 5FU/oxaliplatin combination after first-line gemcitabine. Guidelines for management of PA are continuously evolving and need to be regularly updated. This constant progress is made possible through clinical and translational research. However, as each individual case is particular, they cannot substitute to multidisciplinary tumor board discussion.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30219670</pmid><doi>10.1016/j.dld.2018.08.008</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-9715-9189</orcidid><orcidid>https://orcid.org/0000-0001-7037-7477</orcidid><orcidid>https://orcid.org/0000-0001-7548-284X</orcidid><orcidid>https://orcid.org/0000-0002-9955-4753</orcidid><orcidid>https://orcid.org/0000-0002-7296-5464</orcidid><orcidid>https://orcid.org/0000-0003-4015-5368</orcidid><orcidid>https://orcid.org/0000-0003-1868-3260</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1590-8658
ispartof Digestive and liver disease, 2018-12, Vol.50 (12), p.1257-1271
issn 1590-8658
1878-3562
language eng
recordid cdi_hal_primary_oai_HAL_hal_02143547v1
source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Antineoplastic Combined Chemotherapy Protocols
Chemotherapy
France
French intergroup clinical practice guidelines
Humans
Life Sciences
Pancreatic adenocarcinoma
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - therapy
Practice Guidelines as Topic
Prognosis
Radiotherapy
Societies, Medical
Surgery
Surgical Procedures, Operative
title Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A53%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pancreatic%20cancer:%20French%20clinical%20practice%20guidelines%20for%20diagnosis,%20treatment%20and%20follow-up%20(SNFGE,%20FFCD,%20GERCOR,%20UNICANCER,%20SFCD,%20SFED,%20SFRO,%20ACHBT,%20AFC)&rft.jtitle=Digestive%20and%20liver%20disease&rft.au=Neuzillet,%20Cindy&rft.aucorp=on%20behalf%20of%20the%20Th%C3%A9saurus%20National%20de%20Canc%C3%A9rologie%20Digestive%20(TNCD)&rft.date=2018-12-01&rft.volume=50&rft.issue=12&rft.spage=1257&rft.epage=1271&rft.pages=1257-1271&rft.issn=1590-8658&rft.eissn=1878-3562&rft_id=info:doi/10.1016/j.dld.2018.08.008&rft_dat=%3Cproquest_hal_p%3E2108251526%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2108251526&rft_id=info:pmid/30219670&rft_els_id=S1590865818308880&rfr_iscdi=true