High-resolution dose-response screening using droplet-based microfluidics

A critical early step in drug discovery is the screening of a chemical library. Typically, promising compounds are identified in a primary screen and then more fully characterized in a dose-response analysis with 7-10 data points per compound. Here, we describe a robust microfluidic approach that in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-01, Vol.109
Hauptverfasser:	Miller, Oliver, Harrak, Abdeslam El, Mangeat, Thomas, Baret, Jean-Christophe, Frenz, Lucas, Debs, Bachir El, Mayot, Estelle, Samuels, Michael L, Rooney, Eamonn K, Dieu, Pierre, Galvan, Martin, Link, Darren R, Griffiths, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Condensed Matter Life Sciences Pharmaceutical sciences Physics
Online-Zugang:	Volltext
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