Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors
The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydro...
Gespeichert in:
| Veröffentlicht in: | Analytica chimica acta 2004-06, Vol.513 (1), p.103-111 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 111 |
|---|---|
| container_issue | 1 |
| container_start_page | 103 |
| container_title | Analytica chimica acta |
| container_volume | 513 |
| creator | Farines, Vincent Monje, Marie-Carmen Telo, Joao Paulo Hnawia, Edouard Sauvain, Michel Nepveu, Françoise |
| description | The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of
trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydroxystilbene, 3,5,4′-trimethoxystilbene and 4,4′-dihydroxy-3,5,3′,5′-tetramethylstilbene were compared to 17β-estradiol and its analogues (2-methoxyestradiol, estrone, 2-hydroxyestradiol and 2-methoxyestrone). Measurement of estrogen receptor-β (ER-β) binding capacity was carried out by a receptor competitor assay associated with fluorescence polarisation detection. The superoxide dismutase (SOD) modulation activity was followed with a spectrophotometric assay using the sequence xanthine/xanthine oxidase-2,3-bis[2-methoxy-4-nitro-sulfo-phenyl]-2
H-tetrazolium-5-carboxanilide (X/XO-XTT). The structure–activity relationship was different for the two series tested. In the estrogenic series, a compound which does not inhibit SOD, is recognized by the ER-β. In contrast for the stilbenic series both properties are parallel each other. |
| doi_str_mv | 10.1016/j.aca.2003.08.065 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02134662v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0003267003011528</els_id><sourcerecordid>S0003267003011528</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-2ed09aa53bb6317e8ebd7fd5d0f607280e455fb4c15297013955c10644a701773</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EEqXwA9iyMDAknB3bScVUIb6kSoAEs-Xal9ZVGkd2iui_x1ERbEyns5_X53sIuaRQUKDyZlNoowsGUBZQFyDFEZnQuipzXjJ-TCaQbnImKzglZzFuUsso8Al5e_Xtvl9j59uY6ZjFXY_BfzmLmXVxuxt0xGzr7a7Vgw8J6WzWulUqMWt8yDAOwa-wywIa7EfknJw0uo148VOn5OPh_v3uKV-8PD7fzRe54cCGnKGFmdaiXC5lSSuscWmrxgoLjYSK1YBciGbJDRVsVgEtZ0IYCpJznbqqKqfk-vDuWreqD26rw1557dTTfKHGs7RhyaVknzSx9MCa4GMM2PwGKKjRn9qo5E-N_hTUKvlLmatDptfR6LYJujMu_gVF-oPkI3d74DAt--kwqGgcdgatS04GZb37Z8o36uyE4w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Farines, Vincent ; Monje, Marie-Carmen ; Telo, Joao Paulo ; Hnawia, Edouard ; Sauvain, Michel ; Nepveu, Françoise</creator><creatorcontrib>Farines, Vincent ; Monje, Marie-Carmen ; Telo, Joao Paulo ; Hnawia, Edouard ; Sauvain, Michel ; Nepveu, Françoise</creatorcontrib><description>The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of
trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydroxystilbene, 3,5,4′-trimethoxystilbene and 4,4′-dihydroxy-3,5,3′,5′-tetramethylstilbene were compared to 17β-estradiol and its analogues (2-methoxyestradiol, estrone, 2-hydroxyestradiol and 2-methoxyestrone). Measurement of estrogen receptor-β (ER-β) binding capacity was carried out by a receptor competitor assay associated with fluorescence polarisation detection. The superoxide dismutase (SOD) modulation activity was followed with a spectrophotometric assay using the sequence xanthine/xanthine oxidase-2,3-bis[2-methoxy-4-nitro-sulfo-phenyl]-2
H-tetrazolium-5-carboxanilide (X/XO-XTT). The structure–activity relationship was different for the two series tested. In the estrogenic series, a compound which does not inhibit SOD, is recognized by the ER-β. In contrast for the stilbenic series both properties are parallel each other.</description><identifier>ISSN: 0003-2670</identifier><identifier>EISSN: 1873-4324</identifier><identifier>DOI: 10.1016/j.aca.2003.08.065</identifier><identifier>CODEN: ACACAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analytical chemistry ; Chemical and Process Engineering ; Chemical engineering ; Chemical Sciences ; Chemistry ; Engineering Sciences ; Estrogen ; Estrogen receptor-β ; Exact sciences and technology ; Polyphenols ; Resveratrol ; Spectrometric and optical methods ; Stilbenic derivatives ; Superoxide dismutase inhibitors</subject><ispartof>Analytica chimica acta, 2004-06, Vol.513 (1), p.103-111</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-2ed09aa53bb6317e8ebd7fd5d0f607280e455fb4c15297013955c10644a701773</citedby><cites>FETCH-LOGICAL-c402t-2ed09aa53bb6317e8ebd7fd5d0f607280e455fb4c15297013955c10644a701773</cites><orcidid>0000-0002-6698-9531</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003267003011528$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,309,310,314,776,780,785,786,881,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15773645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02134662$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Farines, Vincent</creatorcontrib><creatorcontrib>Monje, Marie-Carmen</creatorcontrib><creatorcontrib>Telo, Joao Paulo</creatorcontrib><creatorcontrib>Hnawia, Edouard</creatorcontrib><creatorcontrib>Sauvain, Michel</creatorcontrib><creatorcontrib>Nepveu, Françoise</creatorcontrib><title>Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors</title><title>Analytica chimica acta</title><description>The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of
trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydroxystilbene, 3,5,4′-trimethoxystilbene and 4,4′-dihydroxy-3,5,3′,5′-tetramethylstilbene were compared to 17β-estradiol and its analogues (2-methoxyestradiol, estrone, 2-hydroxyestradiol and 2-methoxyestrone). Measurement of estrogen receptor-β (ER-β) binding capacity was carried out by a receptor competitor assay associated with fluorescence polarisation detection. The superoxide dismutase (SOD) modulation activity was followed with a spectrophotometric assay using the sequence xanthine/xanthine oxidase-2,3-bis[2-methoxy-4-nitro-sulfo-phenyl]-2
H-tetrazolium-5-carboxanilide (X/XO-XTT). The structure–activity relationship was different for the two series tested. In the estrogenic series, a compound which does not inhibit SOD, is recognized by the ER-β. In contrast for the stilbenic series both properties are parallel each other.</description><subject>Analytical chemistry</subject><subject>Chemical and Process Engineering</subject><subject>Chemical engineering</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Engineering Sciences</subject><subject>Estrogen</subject><subject>Estrogen receptor-β</subject><subject>Exact sciences and technology</subject><subject>Polyphenols</subject><subject>Resveratrol</subject><subject>Spectrometric and optical methods</subject><subject>Stilbenic derivatives</subject><subject>Superoxide dismutase inhibitors</subject><issn>0003-2670</issn><issn>1873-4324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EEqXwA9iyMDAknB3bScVUIb6kSoAEs-Xal9ZVGkd2iui_x1ERbEyns5_X53sIuaRQUKDyZlNoowsGUBZQFyDFEZnQuipzXjJ-TCaQbnImKzglZzFuUsso8Al5e_Xtvl9j59uY6ZjFXY_BfzmLmXVxuxt0xGzr7a7Vgw8J6WzWulUqMWt8yDAOwa-wywIa7EfknJw0uo148VOn5OPh_v3uKV-8PD7fzRe54cCGnKGFmdaiXC5lSSuscWmrxgoLjYSK1YBciGbJDRVsVgEtZ0IYCpJznbqqKqfk-vDuWreqD26rw1557dTTfKHGs7RhyaVknzSx9MCa4GMM2PwGKKjRn9qo5E-N_hTUKvlLmatDptfR6LYJujMu_gVF-oPkI3d74DAt--kwqGgcdgatS04GZb37Z8o36uyE4w</recordid><startdate>20040618</startdate><enddate>20040618</enddate><creator>Farines, Vincent</creator><creator>Monje, Marie-Carmen</creator><creator>Telo, Joao Paulo</creator><creator>Hnawia, Edouard</creator><creator>Sauvain, Michel</creator><creator>Nepveu, Françoise</creator><general>Elsevier B.V</general><general>Elsevier</general><general>Elsevier Masson</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-6698-9531</orcidid></search><sort><creationdate>20040618</creationdate><title>Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors</title><author>Farines, Vincent ; Monje, Marie-Carmen ; Telo, Joao Paulo ; Hnawia, Edouard ; Sauvain, Michel ; Nepveu, Françoise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-2ed09aa53bb6317e8ebd7fd5d0f607280e455fb4c15297013955c10644a701773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analytical chemistry</topic><topic>Chemical and Process Engineering</topic><topic>Chemical engineering</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Engineering Sciences</topic><topic>Estrogen</topic><topic>Estrogen receptor-β</topic><topic>Exact sciences and technology</topic><topic>Polyphenols</topic><topic>Resveratrol</topic><topic>Spectrometric and optical methods</topic><topic>Stilbenic derivatives</topic><topic>Superoxide dismutase inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farines, Vincent</creatorcontrib><creatorcontrib>Monje, Marie-Carmen</creatorcontrib><creatorcontrib>Telo, Joao Paulo</creatorcontrib><creatorcontrib>Hnawia, Edouard</creatorcontrib><creatorcontrib>Sauvain, Michel</creatorcontrib><creatorcontrib>Nepveu, Françoise</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Analytica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farines, Vincent</au><au>Monje, Marie-Carmen</au><au>Telo, Joao Paulo</au><au>Hnawia, Edouard</au><au>Sauvain, Michel</au><au>Nepveu, Françoise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors</atitle><jtitle>Analytica chimica acta</jtitle><date>2004-06-18</date><risdate>2004</risdate><volume>513</volume><issue>1</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>0003-2670</issn><eissn>1873-4324</eissn><coden>ACACAM</coden><abstract>The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of
trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydroxystilbene, 3,5,4′-trimethoxystilbene and 4,4′-dihydroxy-3,5,3′,5′-tetramethylstilbene were compared to 17β-estradiol and its analogues (2-methoxyestradiol, estrone, 2-hydroxyestradiol and 2-methoxyestrone). Measurement of estrogen receptor-β (ER-β) binding capacity was carried out by a receptor competitor assay associated with fluorescence polarisation detection. The superoxide dismutase (SOD) modulation activity was followed with a spectrophotometric assay using the sequence xanthine/xanthine oxidase-2,3-bis[2-methoxy-4-nitro-sulfo-phenyl]-2
H-tetrazolium-5-carboxanilide (X/XO-XTT). The structure–activity relationship was different for the two series tested. In the estrogenic series, a compound which does not inhibit SOD, is recognized by the ER-β. In contrast for the stilbenic series both properties are parallel each other.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.aca.2003.08.065</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6698-9531</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2670 |
| ispartof | Analytica chimica acta, 2004-06, Vol.513 (1), p.103-111 |
| issn | 0003-2670 1873-4324 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02134662v1 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Analytical chemistry Chemical and Process Engineering Chemical engineering Chemical Sciences Chemistry Engineering Sciences Estrogen Estrogen receptor-β Exact sciences and technology Polyphenols Resveratrol Spectrometric and optical methods Stilbenic derivatives Superoxide dismutase inhibitors |
| title | Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T20%3A18%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polyphenols%20as%20superoxide%20dismutase%20modulators%20and%20ligands%20for%20estrogen%20receptors&rft.jtitle=Analytica%20chimica%20acta&rft.au=Farines,%20Vincent&rft.date=2004-06-18&rft.volume=513&rft.issue=1&rft.spage=103&rft.epage=111&rft.pages=103-111&rft.issn=0003-2670&rft.eissn=1873-4324&rft.coden=ACACAM&rft_id=info:doi/10.1016/j.aca.2003.08.065&rft_dat=%3Celsevier_hal_p%3ES0003267003011528%3C/elsevier_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S0003267003011528&rfr_iscdi=true |