Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease

Depression is frequent in Parkinson's disease, but its pathophysiology remains unclear. Two recent studies have investigated the role of serotonergic system at the presynaptic level. The objective of the present study was to use positron emission tomography and [18F]MPPF to investigate the role...

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Veröffentlicht in:	Movement disorders 2012-01, Vol.27 (1), p.84-89
Hauptverfasser:	Ballanger, Benedicte, Klinger, Helene, Eche, Julien, Lerond, Jérôme, Vallet, Anne-Evelyne, Le Bars, Didier, Tremblay, Leon, Sgambato-Faure, Véronique, Broussolle, Emmanuel, Thobois, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	[18F]MPPF Adult Aged Aminopyridines - pharmacokinetics Biological and medical sciences Brain - diagnostic imaging Brain - drug effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases depression Depression - diagnostic imaging Depression - etiology Female Fluorine Radioisotopes Humans Life Sciences Magnetic Resonance Imaging Male Medical sciences Middle Aged Neurology Neurons and Cognition Parkinson Parkinson Disease - complications Parkinson Disease - diagnostic imaging PET Piperazines - pharmacokinetics Positron-Emission Tomography Receptor, Serotonin, 5-HT1A - metabolism serotonin Serotonin Antagonists - pharmacokinetics
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