Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells

Endothelin-1 (ET-1) has been implicated in the progression of various cancers, including ovarian carcinoma. We found that the ovarian carcinoma cell lines ES2 and OVCAR3 and tumors from different anatomic sites expressed ET-1 system members [ET receptor A and ET-converting enzyme-1 (ECE-1)]. However...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-11, Vol.68 (22), p.9265-9273
Hauptverfasser:	Rayhman, Oleg, Klipper, Eyal, Muller, Laurent, Davidson, Ben, Reich, Reuven, Meidan, Rina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - genetics Cardiology and cardiovascular system Cell Line, Tumor Cellular Biology Endothelin-1 - antagonists & inhibitors Endothelin-1 - biosynthesis Endothelin-Converting Enzymes Female Human health and pathology Humans Life Sciences Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics Neoplasm Invasiveness Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Receptor, Endothelin A - genetics RNA, Messenger - analysis RNA, Small Interfering - pharmacology
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