Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide
In order to improve healthcare of injured people, deacetylated acemannan extracted from Aloe vera leaves , having high inhibitory properties, was used as an antimicrobial finish on traditional cotton items. Response surface methodology was employed to define quadratic relationships between the polys...
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| Veröffentlicht in: | Cellulose (London) 2019-05, Vol.26 (8), p.4957-4970 |
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| creator | Salah, Fatma El Ghoul, Yassine Alminderej, Fahad M. El Golli-Bennour, Emna Ouanes, Zouhour Maciejak, Olek Jarroux, Nathalie Majdoub, Hatem Sakli, Faouzi |
| description | In order to improve healthcare of injured people, deacetylated acemannan extracted from
Aloe vera leaves
, having high inhibitory properties, was used as an antimicrobial finish on traditional cotton items. Response surface methodology was employed to define quadratic relationships between the polysaccharide grafting degree and the treatment process properties. An optimized modification process, offering the highest funtionalization degree, is obtained. The cellulosic fiber morphology and roughness modifications induced by polymer grafting are revealed using Atomic Force Microscopy and Scanning Electron Microscopy. Infra Red spectroscopy was used to confirm the grafting effectiveness. Thermogravimetric Analysis and Differential Scanning Calorimeter were further employed to confirm chemical modification. Considering the potential use of this new biomaterial, original properties were also studied. Finishing treatment seems to preserve mechanical properties, and hydrophilicity of the cellulosic substrate. MTT assay were done in HepG2 cells to ensure that the obtained dressings are non-toxic. The biomaterial showed high biocompatibility and promoted cell viability. Antimicrobial studies showed that grafting treatment conserved polymer antibacterial activity. Optimized cotton dressings exhibited a significant inhibitory effect against
Staphylococcus aureus
and
Escherichia coli
bacteria, killed respectively at 70.2% and 72.4%.
Graphical abstract |
| doi_str_mv | 10.1007/s10570-019-02419-8 |
| format | Article |
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Aloe vera leaves
, having high inhibitory properties, was used as an antimicrobial finish on traditional cotton items. Response surface methodology was employed to define quadratic relationships between the polysaccharide grafting degree and the treatment process properties. An optimized modification process, offering the highest funtionalization degree, is obtained. The cellulosic fiber morphology and roughness modifications induced by polymer grafting are revealed using Atomic Force Microscopy and Scanning Electron Microscopy. Infra Red spectroscopy was used to confirm the grafting effectiveness. Thermogravimetric Analysis and Differential Scanning Calorimeter were further employed to confirm chemical modification. Considering the potential use of this new biomaterial, original properties were also studied. Finishing treatment seems to preserve mechanical properties, and hydrophilicity of the cellulosic substrate. MTT assay were done in HepG2 cells to ensure that the obtained dressings are non-toxic. The biomaterial showed high biocompatibility and promoted cell viability. Antimicrobial studies showed that grafting treatment conserved polymer antibacterial activity. Optimized cotton dressings exhibited a significant inhibitory effect against
Staphylococcus aureus
and
Escherichia coli
bacteria, killed respectively at 70.2% and 72.4%.
Graphical abstract</description><identifier>ISSN: 0969-0239</identifier><identifier>EISSN: 1572-882X</identifier><identifier>DOI: 10.1007/s10570-019-02419-8</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aloe ; Atomic force microscopy ; Biocompatibility ; Biomedical materials ; Bioorganic Chemistry ; Cellulose fibers ; Ceramics ; Chemical Sciences ; Chemistry ; Chemistry and Materials Science ; Composites ; Cotton ; Differential scanning calorimetry ; E coli ; Glass ; Grafting ; Life Sciences ; Mechanical properties ; Microscopy ; Morphology ; Natural Materials ; Organic Chemistry ; Original Research ; Physical Chemistry ; Polymer Sciences ; Polymers ; Polysaccharides ; Response surface methodology ; Scanning electron microscopy ; Substrates ; Sustainable Development ; Thermogravimetric analysis ; Wound healing</subject><ispartof>Cellulose (London), 2019-05, Vol.26 (8), p.4957-4970</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-5e1d68b721d85fbf8fb14a2e343c5942e849982dc2b04873a5018d39dda56a0b3</citedby><cites>FETCH-LOGICAL-c390t-5e1d68b721d85fbf8fb14a2e343c5942e849982dc2b04873a5018d39dda56a0b3</cites><orcidid>0000-0003-2125-9786 ; 0000-0001-9594-9435 ; 0000-0003-3585-9758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10570-019-02419-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10570-019-02419-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://univ-evry.hal.science/hal-02123953$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Salah, Fatma</creatorcontrib><creatorcontrib>El Ghoul, Yassine</creatorcontrib><creatorcontrib>Alminderej, Fahad M.</creatorcontrib><creatorcontrib>El Golli-Bennour, Emna</creatorcontrib><creatorcontrib>Ouanes, Zouhour</creatorcontrib><creatorcontrib>Maciejak, Olek</creatorcontrib><creatorcontrib>Jarroux, Nathalie</creatorcontrib><creatorcontrib>Majdoub, Hatem</creatorcontrib><creatorcontrib>Sakli, Faouzi</creatorcontrib><title>Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide</title><title>Cellulose (London)</title><addtitle>Cellulose</addtitle><description>In order to improve healthcare of injured people, deacetylated acemannan extracted from
Aloe vera leaves
, having high inhibitory properties, was used as an antimicrobial finish on traditional cotton items. Response surface methodology was employed to define quadratic relationships between the polysaccharide grafting degree and the treatment process properties. An optimized modification process, offering the highest funtionalization degree, is obtained. The cellulosic fiber morphology and roughness modifications induced by polymer grafting are revealed using Atomic Force Microscopy and Scanning Electron Microscopy. Infra Red spectroscopy was used to confirm the grafting effectiveness. Thermogravimetric Analysis and Differential Scanning Calorimeter were further employed to confirm chemical modification. Considering the potential use of this new biomaterial, original properties were also studied. Finishing treatment seems to preserve mechanical properties, and hydrophilicity of the cellulosic substrate. MTT assay were done in HepG2 cells to ensure that the obtained dressings are non-toxic. The biomaterial showed high biocompatibility and promoted cell viability. Antimicrobial studies showed that grafting treatment conserved polymer antibacterial activity. Optimized cotton dressings exhibited a significant inhibitory effect against
Staphylococcus aureus
and
Escherichia coli
bacteria, killed respectively at 70.2% and 72.4%.
Graphical abstract</description><subject>Aloe</subject><subject>Atomic force microscopy</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bioorganic Chemistry</subject><subject>Cellulose fibers</subject><subject>Ceramics</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Cotton</subject><subject>Differential scanning calorimetry</subject><subject>E coli</subject><subject>Glass</subject><subject>Grafting</subject><subject>Life Sciences</subject><subject>Mechanical properties</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Natural Materials</subject><subject>Organic Chemistry</subject><subject>Original Research</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Polysaccharides</subject><subject>Response surface methodology</subject><subject>Scanning electron microscopy</subject><subject>Substrates</subject><subject>Sustainable Development</subject><subject>Thermogravimetric analysis</subject><subject>Wound healing</subject><issn>0969-0239</issn><issn>1572-882X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu3CAQhlGVSt2mfYGekHqKFCcD2Gs4rtK0ibRSL63UG8Iw3hCxxgXvRslD9JmL6yq55QIS8_3_DPMT8onBBQNoLzODpoUKmKqA1-WUb8iKNS2vpOS_TsgK1HouCfWOvM_5HgBUy9mK_PmCRwxx3OMwnVN7Z5KxEyb_ZCYfh3NqBkc7H0PceWsCNTljzjNMYz8XbNyPBe0CUoshHELM3tKHeCg6lwrrhx3dJdNP6OgmRKRHTGZWlj7-iHSM4TEbO3f2Dj-Qt70JGT_-v0_Jz6_XP65uqu33b7dXm21lhYKpapC5tezKD5xs-q6Xfcdqw1HUwjaq5ihrpSR3lndQy1aYBph0QjlnmrWBTpySs8X3zgQ9Jr836VFH4_XNZqvnN-CsLKsRR1bYzws7pvj7gHnS9_GQhjKe5pyDBFE2Xii-UDbFnBP2z7YM9JyRXjLSJSP9LyMti0gsolzgYYfpxfoV1V_A1JcF</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Salah, Fatma</creator><creator>El Ghoul, Yassine</creator><creator>Alminderej, Fahad M.</creator><creator>El Golli-Bennour, Emna</creator><creator>Ouanes, Zouhour</creator><creator>Maciejak, Olek</creator><creator>Jarroux, Nathalie</creator><creator>Majdoub, Hatem</creator><creator>Sakli, Faouzi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2125-9786</orcidid><orcidid>https://orcid.org/0000-0001-9594-9435</orcidid><orcidid>https://orcid.org/0000-0003-3585-9758</orcidid></search><sort><creationdate>20190501</creationdate><title>Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide</title><author>Salah, Fatma ; El Ghoul, Yassine ; Alminderej, Fahad M. ; El Golli-Bennour, Emna ; Ouanes, Zouhour ; Maciejak, Olek ; Jarroux, Nathalie ; Majdoub, Hatem ; Sakli, Faouzi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5e1d68b721d85fbf8fb14a2e343c5942e849982dc2b04873a5018d39dda56a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aloe</topic><topic>Atomic force microscopy</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bioorganic Chemistry</topic><topic>Cellulose fibers</topic><topic>Ceramics</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Composites</topic><topic>Cotton</topic><topic>Differential scanning calorimetry</topic><topic>E coli</topic><topic>Glass</topic><topic>Grafting</topic><topic>Life Sciences</topic><topic>Mechanical properties</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Natural Materials</topic><topic>Organic Chemistry</topic><topic>Original Research</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Polysaccharides</topic><topic>Response surface methodology</topic><topic>Scanning electron microscopy</topic><topic>Substrates</topic><topic>Sustainable Development</topic><topic>Thermogravimetric analysis</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salah, Fatma</creatorcontrib><creatorcontrib>El Ghoul, Yassine</creatorcontrib><creatorcontrib>Alminderej, Fahad M.</creatorcontrib><creatorcontrib>El Golli-Bennour, Emna</creatorcontrib><creatorcontrib>Ouanes, Zouhour</creatorcontrib><creatorcontrib>Maciejak, Olek</creatorcontrib><creatorcontrib>Jarroux, Nathalie</creatorcontrib><creatorcontrib>Majdoub, Hatem</creatorcontrib><creatorcontrib>Sakli, Faouzi</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Cellulose (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salah, Fatma</au><au>El Ghoul, Yassine</au><au>Alminderej, Fahad M.</au><au>El Golli-Bennour, Emna</au><au>Ouanes, Zouhour</au><au>Maciejak, Olek</au><au>Jarroux, Nathalie</au><au>Majdoub, Hatem</au><au>Sakli, Faouzi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide</atitle><jtitle>Cellulose (London)</jtitle><stitle>Cellulose</stitle><date>2019-05-01</date><risdate>2019</risdate><volume>26</volume><issue>8</issue><spage>4957</spage><epage>4970</epage><pages>4957-4970</pages><issn>0969-0239</issn><eissn>1572-882X</eissn><abstract>In order to improve healthcare of injured people, deacetylated acemannan extracted from
Aloe vera leaves
, having high inhibitory properties, was used as an antimicrobial finish on traditional cotton items. Response surface methodology was employed to define quadratic relationships between the polysaccharide grafting degree and the treatment process properties. An optimized modification process, offering the highest funtionalization degree, is obtained. The cellulosic fiber morphology and roughness modifications induced by polymer grafting are revealed using Atomic Force Microscopy and Scanning Electron Microscopy. Infra Red spectroscopy was used to confirm the grafting effectiveness. Thermogravimetric Analysis and Differential Scanning Calorimeter were further employed to confirm chemical modification. Considering the potential use of this new biomaterial, original properties were also studied. Finishing treatment seems to preserve mechanical properties, and hydrophilicity of the cellulosic substrate. MTT assay were done in HepG2 cells to ensure that the obtained dressings are non-toxic. The biomaterial showed high biocompatibility and promoted cell viability. Antimicrobial studies showed that grafting treatment conserved polymer antibacterial activity. Optimized cotton dressings exhibited a significant inhibitory effect against
Staphylococcus aureus
and
Escherichia coli
bacteria, killed respectively at 70.2% and 72.4%.
Graphical abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10570-019-02419-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2125-9786</orcidid><orcidid>https://orcid.org/0000-0001-9594-9435</orcidid><orcidid>https://orcid.org/0000-0003-3585-9758</orcidid></addata></record> |
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| ispartof | Cellulose (London), 2019-05, Vol.26 (8), p.4957-4970 |
| issn | 0969-0239 1572-882X |
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| source | SpringerNature Journals |
| subjects | Aloe Atomic force microscopy Biocompatibility Biomedical materials Bioorganic Chemistry Cellulose fibers Ceramics Chemical Sciences Chemistry Chemistry and Materials Science Composites Cotton Differential scanning calorimetry E coli Glass Grafting Life Sciences Mechanical properties Microscopy Morphology Natural Materials Organic Chemistry Original Research Physical Chemistry Polymer Sciences Polymers Polysaccharides Response surface methodology Scanning electron microscopy Substrates Sustainable Development Thermogravimetric analysis Wound healing |
| title | Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide |
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