How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution

The enzyme methylmalonyl-coenzyme A (CoA) mutase, an alphabeta heterodimer of 150 kDa, is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rea...

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Veröffentlicht in:	Structure (London) 1996-03, Vol.4 (3), p.339-350
Hauptverfasser:	Mancia, F, Keep, N H, Nakagawa, A, Leadlay, P F, McSweeney, S, Rasmussen, B, Bösecke, P, Diat, O, Evans, P R
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cobamides - metabolism Condensed Matter Crystallization Crystallography, X-Ray Fluid mechanics Free Radicals - metabolism Ligands Mechanics Methylmalonyl-CoA Mutase - chemistry Models, Molecular Physics Propionibacterium - enzymology Protein Structure, Secondary Soft Condensed Matter Substrate Specificity
Online-Zugang:	Volltext
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