Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics

Human neuroglobin (Ngb) is a hexacoordinated globin which binds some small ligands. Its function is still not well-established, even though Ngb seems to be implicated in the protection against neurodegenerative diseases. It has been shown by molecular dynamics and crystallography that ligand binding...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2019-02, Vol.24 (1), p.39-52
Hauptverfasser:	André, E., Derrien, V., Sebban, P., Assrir, N., Lescop, E., Bernad, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Biochemistry Biochemistry, Molecular Biology Biomedical and Life Sciences Crystallography Cyanides Histidine Humans Inorganic chemistry Kinetics Life Sciences Ligands Microbiology Models, Molecular Mutation Neurodegenerative diseases Neuroglobin Neuroglobin - chemistry Neuroglobin - genetics Neuroglobin - metabolism NMR Nuclear magnetic resonance Original Paper Phenylalanine Point Mutation Protein Binding Protein Stability Protein structure Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Secondary structure Spectroscopy
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