New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids

The synthesis of 3-fluoroalkyl-5-pyrazolecarboxylic acids was achieved by means of an optimised 3-step sequence from fluoroalkyl methylketones and alkyl oxalyl chlorides. [Display omitted] •Convenient alternative to the scarce known methods to prepare 3-fluoroalkyl-5-pyrazolecarboxylates.•Efficient...

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Veröffentlicht in:	Journal of fluorine chemistry 2018-10, Vol.214, p.17-23
Hauptverfasser:	Herrera, Alberto Gómez, Schmitt, Etienne, Panossian, Armen, Vors, Jean-Pierre, Pazenok, Sergii, Leroux, Frédéric R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,5-disubstitution Carboxylic acids Chemical Sciences Chemistry Cyclization Drugs Fluorinated pyrazole Fluorination Hydrazines Hydrocarbons Imines Organic chemistry Vinamide
Online-Zugang:	Volltext
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