Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis

In this study we describe the immunogenicity results from a subset of older people (N = 5187) who participated in a Phase 3 randomized, observer-blinded trial of AS03-TIV versus TIV (Fluarix™) (ClinicalTrials.gov, NCT00753272). Participants received one dose of AS03-TIV or TIV in each study year and...

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Veröffentlicht in:	Human vaccines & immunotherapeutics 2016-12, Vol.12 (12), p.3043-3055
Hauptverfasser:	Ruiz-Palacios, Guillermo M., Leroux-Roels, Geert, Beran, Jiri, Devaster, Jeanne-Marie, Esen, Meral, Launay, Odile, McElhaney, Janet E., van Essen, Gerrit A., Benoit, Anne, Claeys, Carine, Dewé, Walthère, Durand, Christelle, Duval, Xavier, Falsey, Ann R., Feldman, Gregory, Galtier, Florence, Gervais, Pierre, Hwang, Shinn-Jang, McNeil, Shelly, Richardus, Jan Hendrik, Trofa, Andrew, Oostvogels, Lidia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over alpha-Tocopherol - administration & dosage Antibodies, Viral - blood AS03 correlates of protection Drug Combinations Female Geriatry and gerontology Hemagglutination Inhibition Tests Human health and pathology Humans immunogenicity Immunology Infectious diseases Influenza A Virus, H3N2 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - prevention & control Influenza, Human - virology Life Sciences Male older Polysorbates - administration & dosage Research Papers Santé publique et épidémiologie seasonal influenza Single-Blind Method Squalene - administration & dosage Treatment Outcome vaccine Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Vaccinology
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