Hepatitis C virus infection propagates through interactions between Syndecan‐1 and CD81 and impacts the hepatocyte glycocalyx

The hepatitis C virus (HCV) infects hepatocytes after binding to heparan sulfate proteoglycans, in particular Syndecan‐1, followed by recognition of the tetraspanin CD81 and other receptors. Heparan sulfate proteoglycans are found in a specific microenvironment coating the hepatocyte surface called...

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Veröffentlicht in:	Cellular microbiology 2017-05, Vol.19 (5), p.e12711-n/a
Hauptverfasser:	Grigorov, Boyan, Reungoat, Emma, Gentil dit Maurin, Alice, Varbanov, Mihayl, Blaising, Julie, Michelet, Maud, Manuel, Rachel, Parent, Romain, Bartosch, Birke, Zoulim, Fabien, Ruggiero, Florence, Pécheur, Eve‐Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - metabolism Endosomes - metabolism glycocalyx Glycocalyx - metabolism Hep G2 Cells Hepacivirus - physiology Heparan sulfate heparan sulfate proteoglycan Hepatitis hepatitis C Hepatitis C - metabolism Hepatitis C - virology Hepatitis C virus hepatocyte Hepatocytes - metabolism Hepatocytes - virology Host-Pathogen Interactions Humans Infections Life Sciences Pentosyltransferases - metabolism Protein Transport Receptors, Virus - metabolism Syndecan-1 - metabolism tetraspanin Tetraspanin 28 - metabolism UDP Xylose-Protein Xylosyltransferase Virus Replication
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