A large collection of integrated genomically characterized patient‐derived xenografts highlighting the heterogeneity of triple‐negative breast cancer

Triple‐negative breast cancer (TNBC) represents 10% of all breast cancers and is a very heterogeneous disease. Globally, women with TNBC have a poor prognosis, and the development of effective targeted therapies remains a real challenge. Patient‐derived xenografts (PDX) are clinically relevant model...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of cancer 2019-10, Vol.145 (7), p.1902-1912
Hauptverfasser:	Coussy, Florence, Koning, Leanne, Lavigne, Marion, Bernard, Virginie, Ouine, Berengere, Boulai, Anais, El Botty, Rania, Dahmani, Ahmed, Montaudon, Elodie, Assayag, Franck, Morisset, Ludivine, Huguet, Lea, Sourd, Laura, Painsec, Pierre, Callens, Celine, Chateau‐Joubert, Sophie, Servely, Jean‐Luc, Larcher, Thibaut, Reyes, Cecile, Girard, Elodie, Pierron, Gaelle, Laurent, Cecile, Vacher, Sophie, Baulande, Sylvain, Melaabi, Samia, Vincent‐Salomon, Anne, Gentien, David, Dieras, Veronique, Bieche, Ivan, Marangoni, Elisabetta
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antitumor activity Biomarkers Breast cancer Cancer Class I Phosphatidylinositol 3-Kinases - genetics Copy number Female Gene Dosage Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genetic Heterogeneity Genomes GTP Phosphohydrolases - genetics Heterogeneity High-Throughput Nucleotide Sequencing - methods Humans Immunohistochemistry Immunomodulation integrated genomic analysis Life Sciences MAP kinase Medical research Membrane Proteins - genetics Mice Middle Aged Molecular Targeted Therapy Neoplasm Transplantation p53 Protein patient‐derived xenograft Precision Medicine Signal Transduction targeted therapies TOR protein Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology triple‐negative breast cancer Tumor Suppressor Protein p53 - genetics Tumors Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!