GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion

Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features, despite some controversies in age-related studies. GDF11 has been poorly investigated in cancer, particularly in those with stemness capacity, such as hepatoc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2019-06, Vol.1865 (6), p.1540-1554
Hauptverfasser:	Gerardo-Ramírez, Monserrat, Lazzarini-Lechuga, Roberto, Hernández-Rizo, Sharik, Jiménez-Salazar, Javier Esteban, Simoni-Nieves, Arturo, García-Ruiz, Carmen, Fernández-Checa, José Carlos, Marquardt, Jens U., Coulouarn, Cedric, Gutiérrez-Ruiz, María Concepción, Pérez-Aguilar, Benjamín, Gomez-Quiroz, Luis E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Cadherins - genetics Cadherins - metabolism Cancer Cell cycle Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chick Embryo Chorioallantoic Membrane - blood supply Chorioallantoic Membrane - drug effects Cyclin A - genetics Cyclin A - metabolism Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism GDF11 Gene Expression Regulation, Neoplastic Growth Differentiation Factors - genetics Growth Differentiation Factors - metabolism Growth Differentiation Factors - pharmacology HCC Hep G2 Cells Hep3B cells Huh7 cells Human health and pathology Humans Hépatology and Gastroenterology Life Sciences Liver cancer Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Occludin - genetics Occludin - metabolism Signal Transduction Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!