Melanoma addiction to the long non-coding RNA SAMMSON

A known oncogene, MITF , resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON , is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic targ...

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Veröffentlicht in:	Nature (London) 2016-03, Vol.531 (7595), p.518-522
Hauptverfasser:	Leucci, Eleonora, Vendramin, Roberto, Spinazzi, Marco, Laurette, Patrick, Fiers, Mark, Wouters, Jasper, Radaelli, Enrico, Eyckerman, Sven, Leonelli, Carina, Vanderheyden, Katrien, Rogiers, Aljosja, Hermans, Els, Baatsen, Pieter, Aerts, Stein, Amant, Frederic, Van Aelst, Stefan, van den Oord, Joost, de Strooper, Bart, Davidson, Irwin, Lafontaine, Denis L. J., Gevaert, Kris, Vandesompele, Jo, Mestdagh, Pieter, Marine, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/2568 631/67/1059/602 631/67/1813/1634 Animals Binding sites Cancer Carcinogenesis - genetics Carcinogenesis - pathology Cell Lineage Cell Proliferation Cell Survival Chromosomes, Human, Pair 3 - genetics Clone Cells - metabolism Clone Cells - pathology Female Gene amplification Gene Amplification - genetics Gene Knockdown Techniques Genetic aspects Genomes Health aspects Human health and pathology Humanities and Social Sciences Humans Kinases letter Life Sciences Melanoma Melanoma - genetics Melanoma - pathology Melanoma - therapy Metabolism Mice Microphthalmia-Associated Transcription Factor - genetics Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proteins - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molecular Targeted Therapy multidisciplinary Oncogenes - genetics Oncology, Experimental Proteins Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - therapeutic use Science SOXE Transcription Factors - metabolism Xenograft Model Antitumor Assays
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