Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin

Neurotoxicity remains the most common adverse effect of oxaliplatin, limiting its clinical use. In the present study, we developed a mouse model of chronic oxaliplatin-induced neuropathy, which mimics both sensory and motor deficits observed in patients, in a clinically relevant time course. Repeate...

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Veröffentlicht in:	Neuropharmacology 2018-09, Vol.140, p.43-61
Hauptverfasser:	Poupon, Laura, Lamoine, Sylvain, Pereira, Vanessa, Barriere, David A., Lolignier, Stéphane, Giraudet, Fabrice, Aissouni, Youssef, Meleine, Mathieu, Prival, Laëtitia, Richard, Damien, Kerckhove, Nicolas, Authier, Nicolas, Balayssac, David, Eschalier, Alain, Lazdunski, Michel, Busserolles, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Life Sciences Neurotoxicity Oxaliplatin Prevention Riluzole TREK-1 potassium channel
Online-Zugang:	Volltext
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