Discovery of target based novel pyrrolyl phenoxy derivatives as antimycobacterial agents: An in silico approach

A new series of pyrrolyl phenoxy derivatives bearing alkoxy linker were synthesized and evaluated for anti-tubercular activity (anti-TB) against Mycobacterium tuberculosis. Molecular modeling, pharmacophore constructed using GALAHAD to produce an effective alignment of data set and evaluated by Pare...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-04, Vol.94, p.317-339
Hauptverfasser:	More, Uttam A., Joshi, Shrinivas D., Aminabhavi, Tejraj M., Kulkarni, Venkatrao H., Badiger, Aravind M., Lherbet, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-tubercular activity Chemical Sciences Computer Simulation Dose-Response Relationship, Drug Drug Discovery Enoyl ACP reductase Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Pharmacophore Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology Pyrrolyl phenoxy derivatives Structure-Activity Relationship Surflex-docking
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