Nucleoside analogue delivery systems in cancer therapy

Nucleoside analogues (NAs) are important agents in the treatment of hematological malignancies. They are prodrugs that require activation by phosphorylation. Their rapid catabolism, cell resistance and overdistribution in the body jeopardize nucleoside analogue chemotherapy. Accordingly, therapeutic...

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Veröffentlicht in:	Expert opinion on drug delivery 2007-09, Vol.4 (5), p.513-531
Hauptverfasser:	Diab, Roudayna, Degobert, Ghania, Hamoudeh, Misara, Dumontet, Charles, Fessi, Hatem
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics dendrimers DepoFoam Dose-Response Relationship, Drug Drug Carriers Drug Delivery Systems Drug Resistance, Neoplasm Hematologic Neoplasms - drug therapy Humans inclusion complexes Life Sciences liposomes microparticles nanoparticles Nucleosides - administration & dosage Nucleosides - chemistry Nucleosides - pharmacokinetics particles Pharmaceutical sciences polymeric micelles polyplex nanogels Prodrugs Stealth Technology, Pharmaceutical vesicular phospholipid gel
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