Analysis of Fluoroquinolone-mediated Photosensitization of 2′-Deoxyguanosine, Calf Thymus and Cellular DNA: Determination of Type-I, Type-II and Triplet–Triplet Energy Transfer Mechanism Contribution

Fluoroquinolone (FQ) antibacterials are known to exhibit photosensitization properties leading to the formation of oxidative damage to DNA. In addition, photoexcited lomefloxacin (Lome) was recently shown to induce the formation of cyclobutane pyrimidine dimers via triplet–triplet energy transfer. T...

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Veröffentlicht in:	Photochemistry and photobiology 2001-03, Vol.73 (3), p.230-237
Hauptverfasser:	Sauvaigo, Sylvie, Douki, Thierry, Odin, Francette, Caillat, Sylvain, Ravanat, Jean-Luc, Cadet, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	2'-deoxyguanosine Analytical chemistry Animals Anti-Infective Agents - pharmacology Cattle Chemical Sciences Comet Assay Deoxyguanosine - chemistry DNA - drug effects DNA - radiation effects Energy Transfer enozacin fluoroquinolone Fluoroquinolones Life Sciences norfloxacin ofloxacin PHOTOCHEMISTRY, PHOTOPHYSICS AND PHOTOTECHNOLOGY Photosensitizing Agents - pharmacology Thymus Gland - drug effects Thymus Gland - radiation effects Toxicology
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