Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode
Essentials Is remote exposure to major venous thromboembolism (VTE) risk factor related to lower recurrence? We analyzed data from the REVERSE study, a cohort of patients with no recent major risk factor. We found no association between remote risk factors and the risk of recurrence. Patients with r...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2017-10, Vol.15 (10), p.1977-1980 |
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| container_title | Journal of thrombosis and haemostasis |
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| creator | Farren‐Dai, L. Carrier, M. Kovacs, J. Rodger, M. Kovacs, M. J. Le Gal, G. Wells, P. S. Ramsay, T. Kahn, S. R. Chagnon, I. Solymoss, S. Anderson, D. A. Crowther, M. White, R. |
| description | Essentials
Is remote exposure to major venous thromboembolism (VTE) risk factor related to lower recurrence?
We analyzed data from the REVERSE study, a cohort of patients with no recent major risk factor.
We found no association between remote risk factors and the risk of recurrence.
Patients with remote VTE risk factor should be managed as having had an unprovoked VTE.
Summary
Background
It has been shown that the risk of recurrence of venous thromboembolism (VTE) is significantly lower when provoked by a major risk factor such as surgery or trauma compared with an event that was unprovoked.
Objectives
In this study we aimed to assess the association between remote exposure (3–12 months prior to VTE) to major VTE risk factors and the risk of recurrent VTE.
Methods
This was a post‐hoc analysis of the REVERSE study, a prospective cohort of 646 patients with a first VTE, not provoked by a recent ( |
| doi_str_mv | 10.1111/jth.13796 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02048579v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1947504070</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4226-1b9b9a7198d768b2bf81c7b7b13f609f8c2fec5f210b6171ba4db5c4d605cf393</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVpaT7aQ_9AEPTSHDbRh21ZxyWk3ZaFXtKzkOQRq41tbSR5l9zy06utkxQKFQwSMw_vjOZF6BMlV7Sc623eXFEuZPMGndKatwvR8ubty1tyfoLOUtoSQmXNyHt0wloh61I8RU_LlIL1OvswYgP5ADDiCEPIgAe9DRHvYQxTwnkTw2AClOh9GnD06R47bXOICeuxKwDMyeCKgJ1ihNEC1i5DxBo7H1PG07iLYR_uocOw8yl08AG9c7pP8PH5Pke_vt7e3awW65_fvt8s1wtbMdYsqJFGakFl24mmNcy4llphhKHcNUS61jIHtnaMEtNQQY2uOlPbqmtIbR2X_Bxdzrob3atd9IOOjypor1bLtTrmCCNVWwu5p4X9MrNl2IcJUlaDTxb6Xo9QdqGoZMcNc1YV9PM_6DZMcSw_KVQlalIRQf42tzGkFMG9TkCJOlqoioXqj4WFvXhWnMwA3Sv54lkBrmfg4Ht4_L-S-nG3miV_Aww4pvE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1947504070</pqid></control><display><type>article</type><title>Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Farren‐Dai, L. ; Carrier, M. ; Kovacs, J. ; Rodger, M. ; Kovacs, M. J. ; Le Gal, G. ; Wells, P. S. ; Ramsay, T. ; Kahn, S. R. ; Chagnon, I. ; Solymoss, S. ; Anderson, D. A. ; Crowther, M. ; White, R.</creator><creatorcontrib>Farren‐Dai, L. ; Carrier, M. ; Kovacs, J. ; Rodger, M. ; Kovacs, M. J. ; Le Gal, G. ; Wells, P. S. ; Ramsay, T. ; Kahn, S. R. ; Chagnon, I. ; Solymoss, S. ; Anderson, D. A. ; Crowther, M. ; White, R. ; REVERSE investigators</creatorcontrib><description>Essentials
Is remote exposure to major venous thromboembolism (VTE) risk factor related to lower recurrence?
We analyzed data from the REVERSE study, a cohort of patients with no recent major risk factor.
We found no association between remote risk factors and the risk of recurrence.
Patients with remote VTE risk factor should be managed as having had an unprovoked VTE.
Summary
Background
It has been shown that the risk of recurrence of venous thromboembolism (VTE) is significantly lower when provoked by a major risk factor such as surgery or trauma compared with an event that was unprovoked.
Objectives
In this study we aimed to assess the association between remote exposure (3–12 months prior to VTE) to major VTE risk factors and the risk of recurrent VTE.
Methods
This was a post‐hoc analysis of the REVERSE study, a prospective cohort of 646 patients with a first VTE, not provoked by a recent (< 3 months) major risk factor.
Results
We found no difference in the recurrence rate in patients with or without remote exposure to major VTE risk factors, including immobilization (hazard‐ratio [HR], 1.4; 95% confidence interval, 0.7–2.6), surgery (HR, 0.8; 0.3–1.9) and trauma (HR, 1.3; 0.5–3.6).
Conclusion
None of the tested risk factors were associated with a lower risk of recurrence during follow‐up. Patients with remote exposure to major risk factors at the time of a first VTE should not be managed differently from patients with no VTE risk factors.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/jth.13796</identifier><identifier>PMID: 28795538</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Cardiology and cardiovascular system ; cohort study ; Data processing ; Health risk assessment ; Human health and pathology ; Humans ; Immobilization ; Kaplan-Meier Estimate ; Life Sciences ; prognosis provoked ; Proportional Hazards Models ; Pulmonary Embolism - diagnosis ; Pulmonary Embolism - epidemiology ; Pulmonary Embolism - therapy ; Recurrence ; Risk Assessment ; Risk Factors ; Surgery ; Thromboembolism ; Time Factors ; Trauma ; venous thromboembolism ; Venous Thromboembolism - diagnosis ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - therapy ; Venous Thrombosis - diagnosis ; Venous Thrombosis - epidemiology ; Venous Thrombosis - therapy</subject><ispartof>Journal of thrombosis and haemostasis, 2017-10, Vol.15 (10), p.1977-1980</ispartof><rights>2017 International Society on Thrombosis and Haemostasis</rights><rights>2017 International Society on Thrombosis and Haemostasis.</rights><rights>Copyright © 2017 International Society on Thrombosis and Haemostasis</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4226-1b9b9a7198d768b2bf81c7b7b13f609f8c2fec5f210b6171ba4db5c4d605cf393</citedby><cites>FETCH-LOGICAL-c4226-1b9b9a7198d768b2bf81c7b7b13f609f8c2fec5f210b6171ba4db5c4d605cf393</cites><orcidid>0000-0002-9253-248X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28795538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-brest.fr/hal-02048579$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Farren‐Dai, L.</creatorcontrib><creatorcontrib>Carrier, M.</creatorcontrib><creatorcontrib>Kovacs, J.</creatorcontrib><creatorcontrib>Rodger, M.</creatorcontrib><creatorcontrib>Kovacs, M. J.</creatorcontrib><creatorcontrib>Le Gal, G.</creatorcontrib><creatorcontrib>Wells, P. S.</creatorcontrib><creatorcontrib>Ramsay, T.</creatorcontrib><creatorcontrib>Kahn, S. R.</creatorcontrib><creatorcontrib>Chagnon, I.</creatorcontrib><creatorcontrib>Solymoss, S.</creatorcontrib><creatorcontrib>Anderson, D. A.</creatorcontrib><creatorcontrib>Crowther, M.</creatorcontrib><creatorcontrib>White, R.</creatorcontrib><creatorcontrib>REVERSE investigators</creatorcontrib><title>Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Essentials
Is remote exposure to major venous thromboembolism (VTE) risk factor related to lower recurrence?
We analyzed data from the REVERSE study, a cohort of patients with no recent major risk factor.
We found no association between remote risk factors and the risk of recurrence.
Patients with remote VTE risk factor should be managed as having had an unprovoked VTE.
Summary
Background
It has been shown that the risk of recurrence of venous thromboembolism (VTE) is significantly lower when provoked by a major risk factor such as surgery or trauma compared with an event that was unprovoked.
Objectives
In this study we aimed to assess the association between remote exposure (3–12 months prior to VTE) to major VTE risk factors and the risk of recurrent VTE.
Methods
This was a post‐hoc analysis of the REVERSE study, a prospective cohort of 646 patients with a first VTE, not provoked by a recent (< 3 months) major risk factor.
Results
We found no difference in the recurrence rate in patients with or without remote exposure to major VTE risk factors, including immobilization (hazard‐ratio [HR], 1.4; 95% confidence interval, 0.7–2.6), surgery (HR, 0.8; 0.3–1.9) and trauma (HR, 1.3; 0.5–3.6).
Conclusion
None of the tested risk factors were associated with a lower risk of recurrence during follow‐up. Patients with remote exposure to major risk factors at the time of a first VTE should not be managed differently from patients with no VTE risk factors.</description><subject>Cardiology and cardiovascular system</subject><subject>cohort study</subject><subject>Data processing</subject><subject>Health risk assessment</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Immobilization</subject><subject>Kaplan-Meier Estimate</subject><subject>Life Sciences</subject><subject>prognosis provoked</subject><subject>Proportional Hazards Models</subject><subject>Pulmonary Embolism - diagnosis</subject><subject>Pulmonary Embolism - epidemiology</subject><subject>Pulmonary Embolism - therapy</subject><subject>Recurrence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Thromboembolism</subject><subject>Time Factors</subject><subject>Trauma</subject><subject>venous thromboembolism</subject><subject>Venous Thromboembolism - diagnosis</subject><subject>Venous Thromboembolism - epidemiology</subject><subject>Venous Thromboembolism - therapy</subject><subject>Venous Thrombosis - diagnosis</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - therapy</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1r3DAQhkVpaT7aQ_9AEPTSHDbRh21ZxyWk3ZaFXtKzkOQRq41tbSR5l9zy06utkxQKFQwSMw_vjOZF6BMlV7Sc623eXFEuZPMGndKatwvR8ubty1tyfoLOUtoSQmXNyHt0wloh61I8RU_LlIL1OvswYgP5ADDiCEPIgAe9DRHvYQxTwnkTw2AClOh9GnD06R47bXOICeuxKwDMyeCKgJ1ihNEC1i5DxBo7H1PG07iLYR_uocOw8yl08AG9c7pP8PH5Pke_vt7e3awW65_fvt8s1wtbMdYsqJFGakFl24mmNcy4llphhKHcNUS61jIHtnaMEtNQQY2uOlPbqmtIbR2X_Bxdzrob3atd9IOOjypor1bLtTrmCCNVWwu5p4X9MrNl2IcJUlaDTxb6Xo9QdqGoZMcNc1YV9PM_6DZMcSw_KVQlalIRQf42tzGkFMG9TkCJOlqoioXqj4WFvXhWnMwA3Sv54lkBrmfg4Ht4_L-S-nG3miV_Aww4pvE</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Farren‐Dai, L.</creator><creator>Carrier, M.</creator><creator>Kovacs, J.</creator><creator>Rodger, M.</creator><creator>Kovacs, M. J.</creator><creator>Le Gal, G.</creator><creator>Wells, P. S.</creator><creator>Ramsay, T.</creator><creator>Kahn, S. R.</creator><creator>Chagnon, I.</creator><creator>Solymoss, S.</creator><creator>Anderson, D. A.</creator><creator>Crowther, M.</creator><creator>White, R.</creator><general>Elsevier Limited</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9253-248X</orcidid></search><sort><creationdate>201710</creationdate><title>Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode</title><author>Farren‐Dai, L. ; Carrier, M. ; Kovacs, J. ; Rodger, M. ; Kovacs, M. J. ; Le Gal, G. ; Wells, P. S. ; Ramsay, T. ; Kahn, S. R. ; Chagnon, I. ; Solymoss, S. ; Anderson, D. A. ; Crowther, M. ; White, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4226-1b9b9a7198d768b2bf81c7b7b13f609f8c2fec5f210b6171ba4db5c4d605cf393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cardiology and cardiovascular system</topic><topic>cohort study</topic><topic>Data processing</topic><topic>Health risk assessment</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Immobilization</topic><topic>Kaplan-Meier Estimate</topic><topic>Life Sciences</topic><topic>prognosis provoked</topic><topic>Proportional Hazards Models</topic><topic>Pulmonary Embolism - diagnosis</topic><topic>Pulmonary Embolism - epidemiology</topic><topic>Pulmonary Embolism - therapy</topic><topic>Recurrence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Thromboembolism</topic><topic>Time Factors</topic><topic>Trauma</topic><topic>venous thromboembolism</topic><topic>Venous Thromboembolism - diagnosis</topic><topic>Venous Thromboembolism - epidemiology</topic><topic>Venous Thromboembolism - therapy</topic><topic>Venous Thrombosis - diagnosis</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farren‐Dai, L.</creatorcontrib><creatorcontrib>Carrier, M.</creatorcontrib><creatorcontrib>Kovacs, J.</creatorcontrib><creatorcontrib>Rodger, M.</creatorcontrib><creatorcontrib>Kovacs, M. J.</creatorcontrib><creatorcontrib>Le Gal, G.</creatorcontrib><creatorcontrib>Wells, P. S.</creatorcontrib><creatorcontrib>Ramsay, T.</creatorcontrib><creatorcontrib>Kahn, S. R.</creatorcontrib><creatorcontrib>Chagnon, I.</creatorcontrib><creatorcontrib>Solymoss, S.</creatorcontrib><creatorcontrib>Anderson, D. A.</creatorcontrib><creatorcontrib>Crowther, M.</creatorcontrib><creatorcontrib>White, R.</creatorcontrib><creatorcontrib>REVERSE investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farren‐Dai, L.</au><au>Carrier, M.</au><au>Kovacs, J.</au><au>Rodger, M.</au><au>Kovacs, M. J.</au><au>Le Gal, G.</au><au>Wells, P. S.</au><au>Ramsay, T.</au><au>Kahn, S. R.</au><au>Chagnon, I.</au><au>Solymoss, S.</au><au>Anderson, D. A.</au><au>Crowther, M.</au><au>White, R.</au><aucorp>REVERSE investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2017-10</date><risdate>2017</risdate><volume>15</volume><issue>10</issue><spage>1977</spage><epage>1980</epage><pages>1977-1980</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Essentials
Is remote exposure to major venous thromboembolism (VTE) risk factor related to lower recurrence?
We analyzed data from the REVERSE study, a cohort of patients with no recent major risk factor.
We found no association between remote risk factors and the risk of recurrence.
Patients with remote VTE risk factor should be managed as having had an unprovoked VTE.
Summary
Background
It has been shown that the risk of recurrence of venous thromboembolism (VTE) is significantly lower when provoked by a major risk factor such as surgery or trauma compared with an event that was unprovoked.
Objectives
In this study we aimed to assess the association between remote exposure (3–12 months prior to VTE) to major VTE risk factors and the risk of recurrent VTE.
Methods
This was a post‐hoc analysis of the REVERSE study, a prospective cohort of 646 patients with a first VTE, not provoked by a recent (< 3 months) major risk factor.
Results
We found no difference in the recurrence rate in patients with or without remote exposure to major VTE risk factors, including immobilization (hazard‐ratio [HR], 1.4; 95% confidence interval, 0.7–2.6), surgery (HR, 0.8; 0.3–1.9) and trauma (HR, 1.3; 0.5–3.6).
Conclusion
None of the tested risk factors were associated with a lower risk of recurrence during follow‐up. Patients with remote exposure to major risk factors at the time of a first VTE should not be managed differently from patients with no VTE risk factors.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>28795538</pmid><doi>10.1111/jth.13796</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9253-248X</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1538-7933 1538-7836 1538-7836 |
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| subjects | Cardiology and cardiovascular system cohort study Data processing Health risk assessment Human health and pathology Humans Immobilization Kaplan-Meier Estimate Life Sciences prognosis provoked Proportional Hazards Models Pulmonary Embolism - diagnosis Pulmonary Embolism - epidemiology Pulmonary Embolism - therapy Recurrence Risk Assessment Risk Factors Surgery Thromboembolism Time Factors Trauma venous thromboembolism Venous Thromboembolism - diagnosis Venous Thromboembolism - epidemiology Venous Thromboembolism - therapy Venous Thrombosis - diagnosis Venous Thrombosis - epidemiology Venous Thrombosis - therapy |
| title | Association between remote major venous thromboembolism risk factors and the risk of recurrence after a first unprovoked episode |
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