Flush with a flash: natural three-component antimicrobial combinations based on S -nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite

-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O ˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO ). Since the production of O ˙ can be controlled by enzymes or by visible light, such otherwise harmless components can b...

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Veröffentlicht in:	MedChemComm 2018-12, Vol.9 (12), p.1994-1999
Hauptverfasser:	Alhasan, Rama, Kharma, Ammar, Nasim, Muhammad Jawad, Abdin, Ahmad Yaman, Bonetti, Justine, Giummelly, Philippe, Ejike, Chukwunonso E C C, Leroy, Pierre, Gaucher, Caroline, Jacob, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antioxidants Biochemistry Biochemistry, Molecular Biology Cascade chemical reactions Cell Behavior Cellular Biology Life Sciences Peroxynitrite Subcellular Processes Superoxide
Online-Zugang:	Volltext
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