Flush with a flash: natural three-component antimicrobial combinations based on S -nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite

-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O ˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO ). Since the production of O ˙ can be controlled by enzymes or by visible light, such otherwise harmless components can b...

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Veröffentlicht in:MedChemComm 2018-12, Vol.9 (12), p.1994-1999
Hauptverfasser: Alhasan, Rama, Kharma, Ammar, Nasim, Muhammad Jawad, Abdin, Ahmad Yaman, Bonetti, Justine, Giummelly, Philippe, Ejike, Chukwunonso E C C, Leroy, Pierre, Gaucher, Caroline, Jacob, Claus
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container_end_page 1999
container_issue 12
container_start_page 1994
container_title MedChemComm
container_volume 9
creator Alhasan, Rama
Kharma, Ammar
Nasim, Muhammad Jawad
Abdin, Ahmad Yaman
Bonetti, Justine
Giummelly, Philippe
Ejike, Chukwunonso E C C
Leroy, Pierre
Gaucher, Caroline
Jacob, Claus
description -Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O ˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO ). Since the production of O ˙ can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.
doi_str_mv 10.1039/c8md00414e
format Article
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source PubMed Central (Open access); Royal Society Of Chemistry Journals 2008-
subjects Antiinfectives and antibacterials
Antioxidants
Biochemistry
Biochemistry, Molecular Biology
Cascade chemical reactions
Cell Behavior
Cellular Biology
Life Sciences
Peroxynitrite
Subcellular Processes
Superoxide
title Flush with a flash: natural three-component antimicrobial combinations based on S -nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite
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