Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water

Hyperpolarized water can selectively enhance NMR signals of rapidly exchanging protons in osteopontin (OPN), a metastasis‐associated intrinsically disordered protein (IDP), at near‐physiological pH and temperature. The transfer of magnetization from hyperpolarized water is limited to solvent‐exposed...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-01, Vol.56 (1), p.389-392
Hauptverfasser:	Kurzbach, Dennis, Canet, Estel, Flamm, Andrea G., Jhajharia, Aditya, Weber, Emmanuelle M. M., Konrat, Robert, Bodenhausen, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Biocompatibility Biomedical materials dynamic nuclear polarization Exchanging Heparin Hydrogen-Ion Concentration hyperpolarized water intrinsically disordered proteins Life Sciences Metastases NMR NMR spectroscopy Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Osteopontin Osteopontin - chemistry Polysaccharides - chemistry Proteins Protons solvent exchange Solvents - chemistry Structural Biology Structural members Temperature Water - chemistry
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