Hepatitis C Virus Envelope Glycoprotein Signatures Are Associated With Treatment Failure and Modulation of Viral Entry and Neutralization

Background. A major challenge for antiviral treatment of hepatitis C virus (HCV) infection is viral resistance, potentially resulting from the high variability of HCV envelope glycoproteins and subsequent selection of strains with enhanced infectivity and/or immune escape. Methods. We used a bioinfo...

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Veröffentlicht in:	The Journal of infectious diseases 2013-04, Vol.207 (8), p.1306-1315
Hauptverfasser:	Schvoerer, Evelyne, Moenne-Loccoz, Rémy, Murray, John M., Velay, Aurélie, Turek, Marine, Fofana, Isabel, Fafi-Kremer, Samira, Erba, Anne-Claire, Habersetzer, François, Doffoël, Michel, Gut, Jean-Pierre, Donlin, Maureen J., Tavis, John E., Zeisel, Mirjam B., Stoll-Keller, Françoise, Baumert, Thomas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino acids Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antiviral Agents - pharmacology Antivirals Biological and medical sciences Computational Biology - methods Female Fundamental and applied biological sciences. Psychology Genotype Genotypes Glycoproteins HEK293 Cells Hepacivirus Hepacivirus - classification Hepacivirus - pathogenicity Hepatitis C - drug therapy Hepatitis C - immunology Hepatitis C - virology Hepatitis C virus Human health and pathology Humans Immune Evasion Infections Infectious diseases Life Sciences Male Medical sciences Medical treatment failures Microbiology Microbiology and Parasitology Middle Aged Miscellaneous Mutagenesis, Site-Directed Mutation Neutralization Tests Ribavirin - pharmacology Signatures Structure-Activity Relationship Treatment Failure Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Virology Virus Internalization - drug effects Viruses
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