Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer

Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with b...

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Veröffentlicht in:	European journal of cancer (1990) 2018-07, Vol.97, p.16-24
Hauptverfasser:	Aparicio, T., Bouché, O., Francois, E., Retornaz, F., Barbier, E., Taieb, J., Kirscher, S., Etienne, P.-L., Faroux, R., Khemissa Akouz, F., El Hajbi, F., Locher, C., Rinaldi, Y., Lecomte, T., Lavau-Denes, S., Baconnier, M., Oden-Gangloff, A., Genet, D., Bedenne, L., Paillaud, E., Zawadi, Mohamed-Ayman, Volet, Julien, Cavaglione, Gérard, Lepere, Céline, Rougier, Philippe, Zaanan, Aziz, Besson, Dominique, Fawzi, Kara Slimane, Adenis, Antoine, Gatineau-Sailliant, Gilles, Brezault, Catherine, Coriat, Romain, Tougeron, David, Hautefeuille, Vincent, Chone, Laurence, Molin, Yann, Seitz, Jean-François, Le Tallec, Véronique Jestin, Ben Abdelghani, Meher, Villing, Anne-Laure, Aouakli, Amar, Sebbagh, Virginie, Bedjaoui, Ahmed, Mitry, Emmanuel, Carola, Elisabeth, Boulat, Olivier, Queuniet, Anne-Marie, Capitain, Olivier, Jouve, Jean-Louis, Baumgaertner, Isabelle, Almaric, Françoise, Bonnetain, Franck, Subtil, Fabien
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autonomy Bevacizumab Bevacizumab - administration & dosage Camptothecin - administration & dosage Cancer Cardiovascular diseases Chemotherapy Clinical trials Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Elderly Female Fluorouracil - administration & dosage Follow-Up Studies Geriatric assessment Geriatrics Humans Immunotherapy Irinotecan - administration & dosage Leucovorin - administration & dosage Life Sciences Male Metastases Monoclonal antibodies Multivariate analysis Neoplasm Metastasis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Nutritional status Older people Patients Predictive factors Prognosis Quality of life Randomization Subgroups Survival Survival Rate Targeted cancer therapy Transposition
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