Phenotypes of lung cancer and statistical interactions between tobacco smoking and occupational exposure to asbestos and crystalline silica from a large case-only study: The CaProMat study
•Smoking is the main factor related to histological type and age at diagnosis.•Additional exposure to asbestos did not modify the effect of smoking.•The effect of smoking was not modified by additional exposure to crystalline silica.•Smoking, asbestos and crystalline silica did not influence tumor l...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-10, Vol.112, p.140-155 |
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| creator | El Zoghbi, Mohamad Salameh, Pascale Stücker, Isabelle Paris, Christophe Pairon, Jean Claude Gislard, Antoine Siemiatycki, Jack Bonneterre, Vincent Clin, Bénédicte Brochard, Patrick Delva, Fleur Lacourt, Aude |
| description | •Smoking is the main factor related to histological type and age at diagnosis.•Additional exposure to asbestos did not modify the effect of smoking.•The effect of smoking was not modified by additional exposure to crystalline silica.•Smoking, asbestos and crystalline silica did not influence tumor location.
The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica.
The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica. Statistical interactions between tobacco smoking and occupational exposure to asbestos or crystalline silica were assessed using unconditional logistic regression models for histological type and tumor location and linear regression models for age at diagnosis.
Tobacco smoking was associated with squamous cell carcinoma and small cell carcinomas as well as an earlier age at diagnosis. Additional exposure to either asbestos or crystalline silica did not modify the effect of tobacco smoking for either histological type or age at diagnosis. Neither tobacco smoking nor occupational exposure to asbestos or crystalline silica influenced tumor location.
Tobacco smoking was the main factor related to histological type and age at diagnosis. Those associations were not modified by occupational exposure to asbestos or crystalline silica. |
| doi_str_mv | 10.1016/j.lungcan.2017.08.007 |
| format | Article |
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The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica.
The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica. Statistical interactions between tobacco smoking and occupational exposure to asbestos or crystalline silica were assessed using unconditional logistic regression models for histological type and tumor location and linear regression models for age at diagnosis.
Tobacco smoking was associated with squamous cell carcinoma and small cell carcinomas as well as an earlier age at diagnosis. Additional exposure to either asbestos or crystalline silica did not modify the effect of tobacco smoking for either histological type or age at diagnosis. Neither tobacco smoking nor occupational exposure to asbestos or crystalline silica influenced tumor location.
Tobacco smoking was the main factor related to histological type and age at diagnosis. Those associations were not modified by occupational exposure to asbestos or crystalline silica.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2017.08.007</identifier><identifier>PMID: 29191587</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Asbestos ; Asbestos - adverse effects ; Canada - epidemiology ; Crystalline silica ; Female ; Humans ; Interaction ; Life Sciences ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Male ; Middle Aged ; Occupational Diseases - diagnosis ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; Occupational Exposure - adverse effects ; Occupational exposures ; Odds Ratio ; Phenotype ; Population Surveillance ; Retrospective Studies ; Santé publique et épidémiologie ; Silicon Dioxide - adverse effects ; Tobacco smoking ; Tobacco Smoking - adverse effects ; Toxicology</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2017-10, Vol.112, p.140-155</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-ff2b49b3542742eaf652ea6cd84c1f9e02aa944bb0b1cb2d5f53e9bb9af29cbd3</citedby><cites>FETCH-LOGICAL-c399t-ff2b49b3542742eaf652ea6cd84c1f9e02aa944bb0b1cb2d5f53e9bb9af29cbd3</cites><orcidid>0000-0003-2353-7102 ; 0000-0002-4323-6406 ; 0000-0001-6417-4980 ; 0000-0002-4780-0772</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2017.08.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29191587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02011188$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>El Zoghbi, Mohamad</creatorcontrib><creatorcontrib>Salameh, Pascale</creatorcontrib><creatorcontrib>Stücker, Isabelle</creatorcontrib><creatorcontrib>Paris, Christophe</creatorcontrib><creatorcontrib>Pairon, Jean Claude</creatorcontrib><creatorcontrib>Gislard, Antoine</creatorcontrib><creatorcontrib>Siemiatycki, Jack</creatorcontrib><creatorcontrib>Bonneterre, Vincent</creatorcontrib><creatorcontrib>Clin, Bénédicte</creatorcontrib><creatorcontrib>Brochard, Patrick</creatorcontrib><creatorcontrib>Delva, Fleur</creatorcontrib><creatorcontrib>Lacourt, Aude</creatorcontrib><title>Phenotypes of lung cancer and statistical interactions between tobacco smoking and occupational exposure to asbestos and crystalline silica from a large case-only study: The CaProMat study</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>•Smoking is the main factor related to histological type and age at diagnosis.•Additional exposure to asbestos did not modify the effect of smoking.•The effect of smoking was not modified by additional exposure to crystalline silica.•Smoking, asbestos and crystalline silica did not influence tumor location.
The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica.
The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica. Statistical interactions between tobacco smoking and occupational exposure to asbestos or crystalline silica were assessed using unconditional logistic regression models for histological type and tumor location and linear regression models for age at diagnosis.
Tobacco smoking was associated with squamous cell carcinoma and small cell carcinomas as well as an earlier age at diagnosis. Additional exposure to either asbestos or crystalline silica did not modify the effect of tobacco smoking for either histological type or age at diagnosis. Neither tobacco smoking nor occupational exposure to asbestos or crystalline silica influenced tumor location.
Tobacco smoking was the main factor related to histological type and age at diagnosis. Those associations were not modified by occupational exposure to asbestos or crystalline silica.</description><subject>Aged</subject><subject>Asbestos</subject><subject>Asbestos - adverse effects</subject><subject>Canada - epidemiology</subject><subject>Crystalline silica</subject><subject>Female</subject><subject>Humans</subject><subject>Interaction</subject><subject>Life Sciences</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occupational Diseases - diagnosis</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational exposures</subject><subject>Odds Ratio</subject><subject>Phenotype</subject><subject>Population Surveillance</subject><subject>Retrospective Studies</subject><subject>Santé publique et épidémiologie</subject><subject>Silicon Dioxide - adverse effects</subject><subject>Tobacco smoking</subject><subject>Tobacco Smoking - adverse effects</subject><subject>Toxicology</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAURS0EYkrhE0BewiLFdpImZoNGFcMgFTGLYW09Oy9TFzcutjOQf5uPw6Fltmxs6ence599CXnN2Yozvn6_X7lxuDMwrATjzYq1K8aaJ2TB20YUbVmKp2SROVnUjIkL8iLGPcsgZ_I5uRCSS163zYI83Oxw8Gk6YqS-p7MnzaYGA4WhozFBsjFZA47aIWEAk6wfItWYfiEONHkNxngaD_6HzdpZ5I0ZjzBzWYW_jz6OATNJIWqMyce_lAlTdnfODkijdTmC9sEfKFAH4Q7zFhELP7gpLzF20wd6u0O6gZvgv0I6zV6SZz24iK_O95J8v_p0u7kutt8-f9lcbgtTSpmKvhe6krqsK9FUAqFf1_lcm66tDO8lMgEgq0prprnRoqv7ukSptYReSKO7cknenXx34NQx2AOESXmw6vpyq-YZyx1w3rb3PLNvT-wx-J9jfq462GjQORjQj1Fx2fCcX-eKlqQ-oSb4GAP2j96cqblktVfnktVcsmKtyiVn3ZtzxKgP2D2q_rWagY8nAPOn3FsMKhqLudTOBjRJdd7-J-IPFBXAhg</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>El Zoghbi, Mohamad</creator><creator>Salameh, Pascale</creator><creator>Stücker, Isabelle</creator><creator>Paris, Christophe</creator><creator>Pairon, Jean Claude</creator><creator>Gislard, Antoine</creator><creator>Siemiatycki, Jack</creator><creator>Bonneterre, Vincent</creator><creator>Clin, Bénédicte</creator><creator>Brochard, Patrick</creator><creator>Delva, Fleur</creator><creator>Lacourt, Aude</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2353-7102</orcidid><orcidid>https://orcid.org/0000-0002-4323-6406</orcidid><orcidid>https://orcid.org/0000-0001-6417-4980</orcidid><orcidid>https://orcid.org/0000-0002-4780-0772</orcidid></search><sort><creationdate>201710</creationdate><title>Phenotypes of lung cancer and statistical interactions between tobacco smoking and occupational exposure to asbestos and crystalline silica from a large case-only study: The CaProMat study</title><author>El Zoghbi, Mohamad ; Salameh, Pascale ; Stücker, Isabelle ; Paris, Christophe ; Pairon, Jean Claude ; Gislard, Antoine ; Siemiatycki, Jack ; Bonneterre, Vincent ; Clin, Bénédicte ; Brochard, Patrick ; Delva, Fleur ; Lacourt, Aude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-ff2b49b3542742eaf652ea6cd84c1f9e02aa944bb0b1cb2d5f53e9bb9af29cbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Asbestos</topic><topic>Asbestos - adverse effects</topic><topic>Canada - epidemiology</topic><topic>Crystalline silica</topic><topic>Female</topic><topic>Humans</topic><topic>Interaction</topic><topic>Life Sciences</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occupational Diseases - diagnosis</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational exposures</topic><topic>Odds Ratio</topic><topic>Phenotype</topic><topic>Population Surveillance</topic><topic>Retrospective Studies</topic><topic>Santé publique et épidémiologie</topic><topic>Silicon Dioxide - adverse effects</topic><topic>Tobacco smoking</topic><topic>Tobacco Smoking - adverse effects</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Zoghbi, Mohamad</creatorcontrib><creatorcontrib>Salameh, Pascale</creatorcontrib><creatorcontrib>Stücker, Isabelle</creatorcontrib><creatorcontrib>Paris, Christophe</creatorcontrib><creatorcontrib>Pairon, Jean Claude</creatorcontrib><creatorcontrib>Gislard, Antoine</creatorcontrib><creatorcontrib>Siemiatycki, Jack</creatorcontrib><creatorcontrib>Bonneterre, Vincent</creatorcontrib><creatorcontrib>Clin, Bénédicte</creatorcontrib><creatorcontrib>Brochard, Patrick</creatorcontrib><creatorcontrib>Delva, Fleur</creatorcontrib><creatorcontrib>Lacourt, Aude</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Zoghbi, Mohamad</au><au>Salameh, Pascale</au><au>Stücker, Isabelle</au><au>Paris, Christophe</au><au>Pairon, Jean Claude</au><au>Gislard, Antoine</au><au>Siemiatycki, Jack</au><au>Bonneterre, Vincent</au><au>Clin, Bénédicte</au><au>Brochard, Patrick</au><au>Delva, Fleur</au><au>Lacourt, Aude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypes of lung cancer and statistical interactions between tobacco smoking and occupational exposure to asbestos and crystalline silica from a large case-only study: The CaProMat study</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2017-10</date><risdate>2017</risdate><volume>112</volume><spage>140</spage><epage>155</epage><pages>140-155</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>•Smoking is the main factor related to histological type and age at diagnosis.•Additional exposure to asbestos did not modify the effect of smoking.•The effect of smoking was not modified by additional exposure to crystalline silica.•Smoking, asbestos and crystalline silica did not influence tumor location.
The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica.
The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica. Statistical interactions between tobacco smoking and occupational exposure to asbestos or crystalline silica were assessed using unconditional logistic regression models for histological type and tumor location and linear regression models for age at diagnosis.
Tobacco smoking was associated with squamous cell carcinoma and small cell carcinomas as well as an earlier age at diagnosis. Additional exposure to either asbestos or crystalline silica did not modify the effect of tobacco smoking for either histological type or age at diagnosis. Neither tobacco smoking nor occupational exposure to asbestos or crystalline silica influenced tumor location.
Tobacco smoking was the main factor related to histological type and age at diagnosis. Those associations were not modified by occupational exposure to asbestos or crystalline silica.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29191587</pmid><doi>10.1016/j.lungcan.2017.08.007</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2353-7102</orcidid><orcidid>https://orcid.org/0000-0002-4323-6406</orcidid><orcidid>https://orcid.org/0000-0001-6417-4980</orcidid><orcidid>https://orcid.org/0000-0002-4780-0772</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-5002 |
| ispartof | Lung cancer (Amsterdam, Netherlands), 2017-10, Vol.112, p.140-155 |
| issn | 0169-5002 1872-8332 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Asbestos Asbestos - adverse effects Canada - epidemiology Crystalline silica Female Humans Interaction Life Sciences Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - epidemiology Lung Neoplasms - etiology Male Middle Aged Occupational Diseases - diagnosis Occupational Diseases - epidemiology Occupational Diseases - etiology Occupational Exposure - adverse effects Occupational exposures Odds Ratio Phenotype Population Surveillance Retrospective Studies Santé publique et épidémiologie Silicon Dioxide - adverse effects Tobacco smoking Tobacco Smoking - adverse effects Toxicology |
| title | Phenotypes of lung cancer and statistical interactions between tobacco smoking and occupational exposure to asbestos and crystalline silica from a large case-only study: The CaProMat study |
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