Dendrimers for drug delivery
Due to their nanometric size, dendrimers have been considered as potentially suitable as new vehicles for drug delivery since their infancy. The association of a dendrimer and a drug may occur in different ways, either through covalent or non-covalent interactions. A non-covalent interaction can be...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-01, Vol.2 (26), p.4055-4066 |
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| container_end_page | 4066 |
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| container_issue | 26 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
| container_volume | 2 |
| creator | Caminade, Anne-Marie Turrin, Cédric-Olivier |
| description | Due to their nanometric size, dendrimers have been considered as potentially suitable as new vehicles for drug delivery since their infancy. The association of a dendrimer and a drug may occur in different ways, either through covalent or non-covalent interactions. A non-covalent interaction can be the simple encapsulation inside dendrimers that enhances the solubility of lipophilic drugs in water, or electrostatic interactions between the surface and charged drugs (or DNA, RNA, or siRNA). The covalent association may occur through stable bonds, in particular for dendrimers that are considered as active per se, or through cleavable bonds that should be cleaved only when reaching the target (often cancerous cells). In addition, the full structure of the dendrimer can be disassembled under the influence of a trigger such as pH variations. This review will present these strategies and their consequences for drug delivery. |
| doi_str_mv | 10.1039/c4tb00171k |
| format | Article |
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This review will present these strategies and their consequences for drug delivery.</description><subject>Chemical Sciences</subject><subject>Coordination chemistry</subject><subject>Covalence</subject><subject>Dendrimers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Electrostatics</subject><subject>Nanostructure</subject><subject>Ribonucleic acids</subject><subject>Strategy</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkc1PwkAQxTdGIwa5eDaGo5pUZ_aru0fED4wkXjDxttlut1otFHcpCf-9RZArc5nJ5JeXN_MIOUO4QWD61vFFBoApfh-QEwoCklSgOtzN8N4hvRi_oC2FUjF-TDqMUokpkyfk_N7P8lBOfYj9og79PDQf_dxX5dKH1Sk5KmwVfW_bu-Tt8WEyHCXj16fn4WCcOK75Ism0YxnkhQcOPAWGmuZcaJGJwjotqBQ-A21Z4TLKNKJSVlLhQWWYOrSMdcnVRvfTVmbeurFhZWpbmtFgbNY7oACpZnqJLXu5Yeeh_ml8XJhpGZ2vKjvzdRMNZSqVCpHKvWj7AQAJQsF-VErg2N63Vr3eoC7UMQZf7BwjmHUkZsgnd3-RvLTwxVa3yaY-36H_AbBf0QqBZQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Caminade, Anne-Marie</creator><creator>Turrin, Cédric-Olivier</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7187-8070</orcidid><orcidid>https://orcid.org/0000-0001-8487-3578</orcidid></search><sort><creationdate>20140101</creationdate><title>Dendrimers for drug delivery</title><author>Caminade, Anne-Marie ; Turrin, Cédric-Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-b9c3b0dfe0404703192d4595b5fac95265eb09a3fcb2391188a625e08b17c1a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chemical Sciences</topic><topic>Coordination chemistry</topic><topic>Covalence</topic><topic>Dendrimers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Electrostatics</topic><topic>Nanostructure</topic><topic>Ribonucleic acids</topic><topic>Strategy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caminade, Anne-Marie</creatorcontrib><creatorcontrib>Turrin, Cédric-Olivier</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of materials chemistry. 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| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2014-01, Vol.2 (26), p.4055-4066 |
| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Alma/SFX Local Collection; Royal Society of Chemistry E-Journals |
| subjects | Chemical Sciences Coordination chemistry Covalence Dendrimers Drug delivery systems Drugs Electrostatics Nanostructure Ribonucleic acids Strategy |
| title | Dendrimers for drug delivery |
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