Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study
Elevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear. We examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological...
Gespeichert in:
| Veröffentlicht in: | Psychological medicine 2015-07, Vol.45 (10), p.2137-2144 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2144 |
|---|---|
| container_issue | 10 |
| container_start_page | 2137 |
| container_title | Psychological medicine |
| container_volume | 45 |
| creator | Virtanen, M. Shipley, M. J. Batty, G. D. Hamer, M. Allan, C. L. Lowe, G. D. Ebmeier, K. P. Akbaraly, T. N. Alenius, H. Haapakoski, R. Singh-Manoux, A. Kivimäki, M. |
| description | Elevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear.
We examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological distress.
Relative to high IL-6 levels, low levels at baseline were associated with symptom resolution at follow-up [age- and sex-adjusted risk ratio (RR) = 1.15, 95% confidence interval (CI) 1.06-1.25]. Further adjustment for covariates had little effect on the association. Symptomatic participants with repeated low IL-6 were more likely to be symptom-free at follow-up compared with those with repeated high IL-6 (RR = 1.21, 95% CI 1.03-1.41). Among the symptomatic participants with elevated IL-6 at baseline, IL-6 decreased along with symptom resolution.
IL-6 is potentially related to the mechanisms underlying recovery from symptoms of mental ill health. Further studies are needed to examine these mechanisms and to confirm the findings in relation to clinical depression. |
| doi_str_mv | 10.1017/S0033291715000070 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02001644v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0033291715000070</cupid><sourcerecordid>3706474871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-10f212c51c57b45c4ce740d42ea64efdeb8e74ce6bc884abbd7c588147ff3ee83</originalsourceid><addsrcrecordid>eNqNkUGL1TAUhYMoznP0B7iRgBtdVHOTNEndDYM6Aw9cqDuhpOntvIxtU5N04P1783jPQRTBbAL3fOckl0PIc2BvgIF--5kxIXgDGmpWjmYPyAakairTaPOQbA5yddDPyJOUbhkDAZI_Jme8VoUQYkO-Xc8Z44jrdz9XitpELV0i9t7lEGkYaNpPSw4TjZjCuGYfZupnuqS924Ux3HhnR9r7lIue3hWzC7sQM0157fdPyaPBjgmfne5z8vXD-y-XV9X208fry4tt5aRkuQI2cOCuBlfrTtZOOtSS9ZKjVRKHHjtTBg5V54yRtut67WpjQOphEIhGnJPXx9ydHdsl-snGfRusb68utu1hxnjZXUl5B4V9dWSXGH6smHI7-eRwHO2MYU0taMWVkUz8B6oa4E0NoAr68g_0NqxxLksXyigONWeyUHCkXAwpRRzuPwusPTTa_tVo8bw4Ja_dhP2941eFBRCnUDt10fc3-Nvb_4z9CUJsqW8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1686215204</pqid></control><display><type>article</type><title>Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study</title><source>MEDLINE</source><source>Cambridge Journals</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>Virtanen, M. ; Shipley, M. J. ; Batty, G. D. ; Hamer, M. ; Allan, C. L. ; Lowe, G. D. ; Ebmeier, K. P. ; Akbaraly, T. N. ; Alenius, H. ; Haapakoski, R. ; Singh-Manoux, A. ; Kivimäki, M.</creator><creatorcontrib>Virtanen, M. ; Shipley, M. J. ; Batty, G. D. ; Hamer, M. ; Allan, C. L. ; Lowe, G. D. ; Ebmeier, K. P. ; Akbaraly, T. N. ; Alenius, H. ; Haapakoski, R. ; Singh-Manoux, A. ; Kivimäki, M.</creatorcontrib><description>Elevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear.
We examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological distress.
Relative to high IL-6 levels, low levels at baseline were associated with symptom resolution at follow-up [age- and sex-adjusted risk ratio (RR) = 1.15, 95% confidence interval (CI) 1.06-1.25]. Further adjustment for covariates had little effect on the association. Symptomatic participants with repeated low IL-6 were more likely to be symptom-free at follow-up compared with those with repeated high IL-6 (RR = 1.21, 95% CI 1.03-1.41). Among the symptomatic participants with elevated IL-6 at baseline, IL-6 decreased along with symptom resolution.
IL-6 is potentially related to the mechanisms underlying recovery from symptoms of mental ill health. Further studies are needed to examine these mechanisms and to confirm the findings in relation to clinical depression.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291715000070</identifier><identifier>PMID: 25697833</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Anxiety ; Chronic Disease - epidemiology ; Cohort Studies ; common mental disorders ; Cytokines ; depression ; Enzyme-Linked Immunosorbent Assay ; Female ; Health Status Indicators ; Humans ; inflammation ; interleukin ; Interleukin-6 - blood ; Life Sciences ; Male ; Mental disorders ; Middle Aged ; Neurons and Cognition ; Original Articles ; recovery ; Remission Induction ; Stress, Psychological - blood ; Stress, Psychological - psychology ; United Kingdom - epidemiology</subject><ispartof>Psychological medicine, 2015-07, Vol.45 (10), p.2137-2144</ispartof><rights>Copyright © Cambridge University Press 2015</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-10f212c51c57b45c4ce740d42ea64efdeb8e74ce6bc884abbd7c588147ff3ee83</citedby><cites>FETCH-LOGICAL-c440t-10f212c51c57b45c4ce740d42ea64efdeb8e74ce6bc884abbd7c588147ff3ee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291715000070/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,780,784,885,12844,27922,27923,30997,55626</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25697833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-02001644$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Virtanen, M.</creatorcontrib><creatorcontrib>Shipley, M. J.</creatorcontrib><creatorcontrib>Batty, G. D.</creatorcontrib><creatorcontrib>Hamer, M.</creatorcontrib><creatorcontrib>Allan, C. L.</creatorcontrib><creatorcontrib>Lowe, G. D.</creatorcontrib><creatorcontrib>Ebmeier, K. P.</creatorcontrib><creatorcontrib>Akbaraly, T. N.</creatorcontrib><creatorcontrib>Alenius, H.</creatorcontrib><creatorcontrib>Haapakoski, R.</creatorcontrib><creatorcontrib>Singh-Manoux, A.</creatorcontrib><creatorcontrib>Kivimäki, M.</creatorcontrib><title>Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Elevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear.
We examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological distress.
Relative to high IL-6 levels, low levels at baseline were associated with symptom resolution at follow-up [age- and sex-adjusted risk ratio (RR) = 1.15, 95% confidence interval (CI) 1.06-1.25]. Further adjustment for covariates had little effect on the association. Symptomatic participants with repeated low IL-6 were more likely to be symptom-free at follow-up compared with those with repeated high IL-6 (RR = 1.21, 95% CI 1.03-1.41). Among the symptomatic participants with elevated IL-6 at baseline, IL-6 decreased along with symptom resolution.
IL-6 is potentially related to the mechanisms underlying recovery from symptoms of mental ill health. Further studies are needed to examine these mechanisms and to confirm the findings in relation to clinical depression.</description><subject>Adult</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Chronic Disease - epidemiology</subject><subject>Cohort Studies</subject><subject>common mental disorders</subject><subject>Cytokines</subject><subject>depression</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>inflammation</subject><subject>interleukin</subject><subject>Interleukin-6 - blood</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Neurons and Cognition</subject><subject>Original Articles</subject><subject>recovery</subject><subject>Remission Induction</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - psychology</subject><subject>United Kingdom - epidemiology</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUGL1TAUhYMoznP0B7iRgBtdVHOTNEndDYM6Aw9cqDuhpOntvIxtU5N04P1783jPQRTBbAL3fOckl0PIc2BvgIF--5kxIXgDGmpWjmYPyAakairTaPOQbA5yddDPyJOUbhkDAZI_Jme8VoUQYkO-Xc8Z44jrdz9XitpELV0i9t7lEGkYaNpPSw4TjZjCuGYfZupnuqS924Ux3HhnR9r7lIue3hWzC7sQM0157fdPyaPBjgmfne5z8vXD-y-XV9X208fry4tt5aRkuQI2cOCuBlfrTtZOOtSS9ZKjVRKHHjtTBg5V54yRtut67WpjQOphEIhGnJPXx9ydHdsl-snGfRusb68utu1hxnjZXUl5B4V9dWSXGH6smHI7-eRwHO2MYU0taMWVkUz8B6oa4E0NoAr68g_0NqxxLksXyigONWeyUHCkXAwpRRzuPwusPTTa_tVo8bw4Ja_dhP2941eFBRCnUDt10fc3-Nvb_4z9CUJsqW8</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Virtanen, M.</creator><creator>Shipley, M. J.</creator><creator>Batty, G. D.</creator><creator>Hamer, M.</creator><creator>Allan, C. L.</creator><creator>Lowe, G. D.</creator><creator>Ebmeier, K. P.</creator><creator>Akbaraly, T. N.</creator><creator>Alenius, H.</creator><creator>Haapakoski, R.</creator><creator>Singh-Manoux, A.</creator><creator>Kivimäki, M.</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20150701</creationdate><title>Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study</title><author>Virtanen, M. ; Shipley, M. J. ; Batty, G. D. ; Hamer, M. ; Allan, C. L. ; Lowe, G. D. ; Ebmeier, K. P. ; Akbaraly, T. N. ; Alenius, H. ; Haapakoski, R. ; Singh-Manoux, A. ; Kivimäki, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-10f212c51c57b45c4ce740d42ea64efdeb8e74ce6bc884abbd7c588147ff3ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Chronic Disease - epidemiology</topic><topic>Cohort Studies</topic><topic>common mental disorders</topic><topic>Cytokines</topic><topic>depression</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>inflammation</topic><topic>interleukin</topic><topic>Interleukin-6 - blood</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Neurons and Cognition</topic><topic>Original Articles</topic><topic>recovery</topic><topic>Remission Induction</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - psychology</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virtanen, M.</creatorcontrib><creatorcontrib>Shipley, M. J.</creatorcontrib><creatorcontrib>Batty, G. D.</creatorcontrib><creatorcontrib>Hamer, M.</creatorcontrib><creatorcontrib>Allan, C. L.</creatorcontrib><creatorcontrib>Lowe, G. D.</creatorcontrib><creatorcontrib>Ebmeier, K. P.</creatorcontrib><creatorcontrib>Akbaraly, T. N.</creatorcontrib><creatorcontrib>Alenius, H.</creatorcontrib><creatorcontrib>Haapakoski, R.</creatorcontrib><creatorcontrib>Singh-Manoux, A.</creatorcontrib><creatorcontrib>Kivimäki, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virtanen, M.</au><au>Shipley, M. J.</au><au>Batty, G. D.</au><au>Hamer, M.</au><au>Allan, C. L.</au><au>Lowe, G. D.</au><au>Ebmeier, K. P.</au><au>Akbaraly, T. N.</au><au>Alenius, H.</au><au>Haapakoski, R.</au><au>Singh-Manoux, A.</au><au>Kivimäki, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>45</volume><issue>10</issue><spage>2137</spage><epage>2144</epage><pages>2137-2144</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Elevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear.
We examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological distress.
Relative to high IL-6 levels, low levels at baseline were associated with symptom resolution at follow-up [age- and sex-adjusted risk ratio (RR) = 1.15, 95% confidence interval (CI) 1.06-1.25]. Further adjustment for covariates had little effect on the association. Symptomatic participants with repeated low IL-6 were more likely to be symptom-free at follow-up compared with those with repeated high IL-6 (RR = 1.21, 95% CI 1.03-1.41). Among the symptomatic participants with elevated IL-6 at baseline, IL-6 decreased along with symptom resolution.
IL-6 is potentially related to the mechanisms underlying recovery from symptoms of mental ill health. Further studies are needed to examine these mechanisms and to confirm the findings in relation to clinical depression.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>25697833</pmid><doi>10.1017/S0033291715000070</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2917 |
| ispartof | Psychological medicine, 2015-07, Vol.45 (10), p.2137-2144 |
| issn | 0033-2917 1469-8978 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02001644v1 |
| source | MEDLINE; Cambridge Journals; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Aged Anxiety Chronic Disease - epidemiology Cohort Studies common mental disorders Cytokines depression Enzyme-Linked Immunosorbent Assay Female Health Status Indicators Humans inflammation interleukin Interleukin-6 - blood Life Sciences Male Mental disorders Middle Aged Neurons and Cognition Original Articles recovery Remission Induction Stress, Psychological - blood Stress, Psychological - psychology United Kingdom - epidemiology |
| title | Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T18%3A19%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-6%20as%20a%20predictor%20of%20symptom%20resolution%20in%20psychological%20distress:%20a%20cohort%20study&rft.jtitle=Psychological%20medicine&rft.au=Virtanen,%20M.&rft.date=2015-07-01&rft.volume=45&rft.issue=10&rft.spage=2137&rft.epage=2144&rft.pages=2137-2144&rft.issn=0033-2917&rft.eissn=1469-8978&rft.coden=PSMDCO&rft_id=info:doi/10.1017/S0033291715000070&rft_dat=%3Cproquest_hal_p%3E3706474871%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1686215204&rft_id=info:pmid/25697833&rft_cupid=10_1017_S0033291715000070&rfr_iscdi=true |