Necrotizing Meningoencephalitis in a Captive Black and White Ruffed Lemur (Varecia variegata variegata) Caused by Acanthamoeba T4 Genotype
A mature male, black and white ruffed lemur (Varecia variegata variegata) died in a zoological garden after a 4-day history of lethargy and non-responsive convulsions. Necropsy and histopathological examinations revealed acute necrotizing and haemorrhagic meningoencephalitis with intralesional amoeb...
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| Veröffentlicht in: | Journal of comparative pathology 2015-11, Vol.153 (4), p.231-235 |
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| creator | Gaide, N. Pelandakis, M. Robveille, C. Albaric, O. Jouvion, G. Souchon, M. Risler, A. Abadie, J. |
| description | A mature male, black and white ruffed lemur (Varecia variegata variegata) died in a zoological garden after a 4-day history of lethargy and non-responsive convulsions. Necropsy and histopathological examinations revealed acute necrotizing and haemorrhagic meningoencephalitis with intralesional amoebas confirmed by immunohistochemistry. Acanthamoeba T4 genotype was identified as the causative agent of the brain lesion, based on amplification and sequencing of 18S ribosomal RNA genes. The presence of free-living amoebas in water and mud from the lemur's environment was investigated by morphological and molecular analyses. The two predominant genera, representing 80% of isolated amoebas, were Naegleria spp. and Acanthamoeba spp. All Acanthamoeba isolates belonged to the T4 genotype. To the author's knowledge, this is the first report of a meningoencephalitis due to Acanthamoeba T4 genotype in Lemuridae with concurrent analysis of pathological tissues and environment. |
| doi_str_mv | 10.1016/j.jcpa.2015.07.005 |
| format | Article |
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Necropsy and histopathological examinations revealed acute necrotizing and haemorrhagic meningoencephalitis with intralesional amoebas confirmed by immunohistochemistry. Acanthamoeba T4 genotype was identified as the causative agent of the brain lesion, based on amplification and sequencing of 18S ribosomal RNA genes. The presence of free-living amoebas in water and mud from the lemur's environment was investigated by morphological and molecular analyses. The two predominant genera, representing 80% of isolated amoebas, were Naegleria spp. and Acanthamoeba spp. All Acanthamoeba isolates belonged to the T4 genotype. 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All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-f3fbd1161f90895c2db6c05fd10e42030a65f07ccf70b8ad5cd07a61386eed043</citedby><cites>FETCH-LOGICAL-c460t-f3fbd1161f90895c2db6c05fd10e42030a65f07ccf70b8ad5cd07a61386eed043</cites><orcidid>0000-0002-7750-0519 ; 0000-0002-6407-5007 ; 0000-0002-8227-1394 ; 0000-0003-0188-2554</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcpa.2015.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26297109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02001312$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaide, N.</creatorcontrib><creatorcontrib>Pelandakis, M.</creatorcontrib><creatorcontrib>Robveille, C.</creatorcontrib><creatorcontrib>Albaric, O.</creatorcontrib><creatorcontrib>Jouvion, G.</creatorcontrib><creatorcontrib>Souchon, M.</creatorcontrib><creatorcontrib>Risler, A.</creatorcontrib><creatorcontrib>Abadie, J.</creatorcontrib><title>Necrotizing Meningoencephalitis in a Captive Black and White Ruffed Lemur (Varecia variegata variegata) Caused by Acanthamoeba T4 Genotype</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>A mature male, black and white ruffed lemur (Varecia variegata variegata) died in a zoological garden after a 4-day history of lethargy and non-responsive convulsions. Necropsy and histopathological examinations revealed acute necrotizing and haemorrhagic meningoencephalitis with intralesional amoebas confirmed by immunohistochemistry. Acanthamoeba T4 genotype was identified as the causative agent of the brain lesion, based on amplification and sequencing of 18S ribosomal RNA genes. The presence of free-living amoebas in water and mud from the lemur's environment was investigated by morphological and molecular analyses. The two predominant genera, representing 80% of isolated amoebas, were Naegleria spp. and Acanthamoeba spp. All Acanthamoeba isolates belonged to the T4 genotype. 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| ispartof | Journal of comparative pathology, 2015-11, Vol.153 (4), p.231-235 |
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| subjects | Acanthamoeba Acanthamoeba - genetics Amebiasis - pathology Amebiasis - veterinary Animals Ecology, environment Genotype lemur Lemur - microbiology Life Sciences Male meningoencephalitis Meningoencephalitis - microbiology Meningoencephalitis - pathology Meningoencephalitis - veterinary Microbiology and Parasitology Necrosis - microbiology Necrosis - veterinary Symbiosis |
| title | Necrotizing Meningoencephalitis in a Captive Black and White Ruffed Lemur (Varecia variegata variegata) Caused by Acanthamoeba T4 Genotype |
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