Effects of leucine and citrulline versus non-essential amino acids on muscle protein synthesis in fasted rat: a common activation pathway?

Leucine (LEU) is recognized as a major regulator of muscle protein synthesis (MPS). Citrulline (CIT) is emerging as a potent new regulator. The aim of our study was to compare MPS modulation by CIT and LEU in food-deprived rats and to determine whether their action was driven by similar mechanisms....

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Veröffentlicht in:	Amino acids 2012-09, Vol.43 (3), p.1171-1178
Hauptverfasser:	Le Plénier, Servane, Walrand, Stéphane, Noirt, Richard, Cynober, Luc, Moinard, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - metabolism Amino acids Analytical Chemistry Animals Biochemical Engineering Biochemistry Biomedical and Life Sciences Blood Glucose Carrier Proteins - metabolism Citrulline - administration & dosage Citrulline - pharmacokinetics Food and Nutrition Food Deprivation Insulin - blood Kinases Leucine Leucine - administration & dosage Leucine - pharmacokinetics Life Sciences Male MAP Kinase Signaling System Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes Muscle Proteins - biosynthesis Muscle, Skeletal - drug effects Muscles Neurobiology Original Article Pathways Phosphoproteins - metabolism Phosphorylation Protein Processing, Post-Translational Proteins - metabolism Proteomics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases - metabolism Saline TOR Serine-Threonine Kinases
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