Pressure‐induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography

Dihydroorotase (DHOase) is involved in the de novo synthesis of pyrimidine in virtually all organisms, and it is usually associated with two other enzymes found in this biosynthetic pathway, carbamylphosphate synthetase and/or aspartate transcarbamylase (ATCase). In the hyperthermophilic bacterium A...

Ausführliche Beschreibung