Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

Primary pulmonary hypertension is a progressive and often fatal disorder in humans that results from an increase in pulmonary blood pressure associated with abnormal vascular proliferation. Dexfenfluramine increases the risk of pulmonary hypertension in humans, and its active metabolite is a selecti...

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Veröffentlicht in:	Nature Medicine 2002-10, Vol.8 (10), p.1129-1135
Hauptverfasser:	Launay, J.-M., Hervé, P., Peoc'h, K., Tournois, C., Callebert, J., Nebigil, C.G., Etienne, N., Drouet, L., Humbert, M., Simonneau, G., Maroteaux, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Biomedical and Life Sciences Biomedicine Blood Pressure Cancer Research Cell Division Dexfenfluramine Dexfenfluramine - metabolism Dexfenfluramine - pharmacology Disease Models, Animal DNA DNA - biosynthesis Female Human health and pathology Humans Hypertension Hypertension, Pulmonary Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypoxia Hypoxia - physiopathology Infectious Diseases Kinases Life Sciences Ligands Lung Lung - blood supply Lung - metabolism Lung - pathology Male Metabolic Diseases Metabolites Mice Molecular Medicine Neurosciences Organ Culture Techniques Pulmonary arteries Pulmonary Artery Pulmonary Artery - metabolism Pulmonary Artery - pathology Pulmonary hypertension Pulmonology and respiratory tract Pyrimidines Pyrimidines - pharmacology Receptor, Serotonin, 5-HT2B Receptors, Serotonin Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Serotonin Serotonin - metabolism Serotonin Antagonists Serotonin Antagonists - metabolism Serotonin Receptor Agonists Serotonin Receptor Agonists - pharmacology Vasoconstriction Veins & arteries
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