The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats
High concentrations of diazepam-binding inhibitor (DBI) have been detected in brain areas containing dopaminergic cell bodies and nerve terminals. In the present study, we have investigated the effect of a proteolytic fragment of DBI, the octadecaneuropeptide ODN, on apomorphine-induced yawning in S...
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| Veröffentlicht in: | European journal of pharmacology 1998-09, Vol.357 (2), p.121-126 |
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| creator | de Mateos-Verchere, Juana Garcia Leprince, Jérôme Tonon, Marie-Christine Vaudry, Hubert Costentin, Jean |
| description | High concentrations of diazepam-binding inhibitor (DBI) have been detected in brain areas containing dopaminergic cell bodies and nerve terminals. In the present study, we have investigated the effect of a proteolytic fragment of DBI, the octadecaneuropeptide ODN, on apomorphine-induced yawning in Sprague–Dawley rats. Injection of graded doses of ODN (12.5 to 100 ng i.c.v.) caused a dose-dependent inhibition of apomorphine-induced yawning and penile erections. At a dose of 100 ng, intracerebroventricularly administered ODN was able to inhibit, during more than 3 h, the apomorphine-evoked yawning. ODN also inhibited pilocarpine-induced yawning. Apomorphine induces a bell-shaped dose-dependent effect on yawning with a maximum response at the dose of 100 μg/kg and a much lower effect at a dose of 200 μg/kg. Injection (i.c.v.) of 100 ng ODN markedly attenuated the number of yawns induced by 100 μg/kg apomorphine but partially restored the yawning behavior in rats treated with a 200 μg/kg dose of apomorphine. At doses of 0.5 or 5 mg/kg s.c., diazepam did not modify the inhibitory effect of ODN on the apomorphine-induced yawning. Taken together, the present data suggest that ODN inhibits yawning downstream dopaminergic as well as cholinergic synapses involved in yawning. In addition, the effect of ODN cannot be ascribed to an inverse agonistic activity on central-type benzodiazepine receptors. |
| doi_str_mv | 10.1016/S0014-2999(98)00570-6 |
| format | Article |
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In the present study, we have investigated the effect of a proteolytic fragment of DBI, the octadecaneuropeptide ODN, on apomorphine-induced yawning in Sprague–Dawley rats. Injection of graded doses of ODN (12.5 to 100 ng i.c.v.) caused a dose-dependent inhibition of apomorphine-induced yawning and penile erections. At a dose of 100 ng, intracerebroventricularly administered ODN was able to inhibit, during more than 3 h, the apomorphine-evoked yawning. ODN also inhibited pilocarpine-induced yawning. Apomorphine induces a bell-shaped dose-dependent effect on yawning with a maximum response at the dose of 100 μg/kg and a much lower effect at a dose of 200 μg/kg. Injection (i.c.v.) of 100 ng ODN markedly attenuated the number of yawns induced by 100 μg/kg apomorphine but partially restored the yawning behavior in rats treated with a 200 μg/kg dose of apomorphine. At doses of 0.5 or 5 mg/kg s.c., diazepam did not modify the inhibitory effect of ODN on the apomorphine-induced yawning. Taken together, the present data suggest that ODN inhibits yawning downstream dopaminergic as well as cholinergic synapses involved in yawning. In addition, the effect of ODN cannot be ascribed to an inverse agonistic activity on central-type benzodiazepine receptors.</description><identifier>ISSN: 0014-2999</identifier><identifier>ISSN: 1879-0712</identifier><identifier>EISSN: 1879-0712</identifier><identifier>EISSN: 0014-2999</identifier><identifier>DOI: 10.1016/S0014-2999(98)00570-6</identifier><identifier>PMID: 9797027</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Apomorphine ; Apomorphine - pharmacology ; Biological and medical sciences ; Carrier Proteins ; Carrier Proteins - pharmacology ; Cell Behavior ; Cellular Biology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Chemical Sciences ; Diazepam ; Diazepam Binding Inhibitor ; Dose-Response Relationship, Drug ; Endozepine ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Life Sciences ; Male ; Medicinal Chemistry ; Neurobiology ; Neurons and Cognition ; Neuropeptides ; Neuropeptides - administration & dosage ; Neuropeptides - pharmacology ; ODN (Octadecaneuropeptide) ; Penile Erection ; Penile Erection - drug effects ; Peptide Fragments ; Pharmaceutical sciences ; Pharmacology ; Pilocarpine ; Pilocarpine - pharmacology ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Vertebrates: nervous system and sense organs ; Yawning ; Yawning - drug effects</subject><ispartof>European journal of pharmacology, 1998-09, Vol.357 (2), p.121-126</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-b85c96f8e53c655d4e2c953537c52f30261a49ef3d066799083f0d04f649684e3</citedby><cites>FETCH-LOGICAL-c425t-b85c96f8e53c655d4e2c953537c52f30261a49ef3d066799083f0d04f649684e3</cites><orcidid>0000-0002-7814-9927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299998005706$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1586388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9797027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-01973047$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>de Mateos-Verchere, Juana Garcia</creatorcontrib><creatorcontrib>Leprince, Jérôme</creatorcontrib><creatorcontrib>Tonon, Marie-Christine</creatorcontrib><creatorcontrib>Vaudry, Hubert</creatorcontrib><creatorcontrib>Costentin, Jean</creatorcontrib><title>The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>High concentrations of diazepam-binding inhibitor (DBI) have been detected in brain areas containing dopaminergic cell bodies and nerve terminals. In the present study, we have investigated the effect of a proteolytic fragment of DBI, the octadecaneuropeptide ODN, on apomorphine-induced yawning in Sprague–Dawley rats. Injection of graded doses of ODN (12.5 to 100 ng i.c.v.) caused a dose-dependent inhibition of apomorphine-induced yawning and penile erections. At a dose of 100 ng, intracerebroventricularly administered ODN was able to inhibit, during more than 3 h, the apomorphine-evoked yawning. ODN also inhibited pilocarpine-induced yawning. Apomorphine induces a bell-shaped dose-dependent effect on yawning with a maximum response at the dose of 100 μg/kg and a much lower effect at a dose of 200 μg/kg. Injection (i.c.v.) of 100 ng ODN markedly attenuated the number of yawns induced by 100 μg/kg apomorphine but partially restored the yawning behavior in rats treated with a 200 μg/kg dose of apomorphine. At doses of 0.5 or 5 mg/kg s.c., diazepam did not modify the inhibitory effect of ODN on the apomorphine-induced yawning. Taken together, the present data suggest that ODN inhibits yawning downstream dopaminergic as well as cholinergic synapses involved in yawning. In addition, the effect of ODN cannot be ascribed to an inverse agonistic activity on central-type benzodiazepine receptors.</description><subject>Animals</subject><subject>Apomorphine</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>Carrier Proteins - pharmacology</subject><subject>Cell Behavior</subject><subject>Cellular Biology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Chemical Sciences</subject><subject>Diazepam</subject><subject>Diazepam Binding Inhibitor</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endozepine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicinal Chemistry</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Neuropeptides</subject><subject>Neuropeptides - administration & dosage</subject><subject>Neuropeptides - pharmacology</subject><subject>ODN (Octadecaneuropeptide)</subject><subject>Penile Erection</subject><subject>Penile Erection - drug effects</subject><subject>Peptide Fragments</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology</subject><subject>Pilocarpine</subject><subject>Pilocarpine - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Yawning</subject><subject>Yawning - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><issn>1879-0712</issn><issn>0014-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1EVZbCT6iUA0LtIXQcx18nVBVoK63aQ8vZ8toT1igbBzsp6r_H211tj5xG8jzzzvgh5JTCFwpUXDwA0LZutNZnWp0DcAm1eEMWVEldg6TNW7I4IO_I-5x_Q6F0w4_JsZZaQiMX5PZxjVV0k_Xo7IBziiOOU_BY3X-7q8KwDqsw5cqOcRPTuA4D1mHws0NfPdu_Qxh-FahKdsofyFFn-4wf9_WE_Pzx_fHqpl7eX99eXS5r1zZ8qleKOy06hZw5wblvsXGaM86k403HoBHUtho75kEIqTUo1oGHthOtFqpFdkLOd7lr25sxhY1NzybaYG4ul2b7BlRLBq18ooX9vGPHFP_MmCezCdlh35evxjkbWQRRrdsC8h3oUsw5YXdIpmC2us2LbrN1abQyL7qNKHOn-wXzaoP-MLX3W_qf9n2bne27ZAcX8ms4V4IpVbCvOwyLuKeAyWQXcCiWQ0I3GR_Dfw75B2O_mho</recordid><startdate>19980918</startdate><enddate>19980918</enddate><creator>de Mateos-Verchere, Juana Garcia</creator><creator>Leprince, Jérôme</creator><creator>Tonon, Marie-Christine</creator><creator>Vaudry, Hubert</creator><creator>Costentin, Jean</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7814-9927</orcidid></search><sort><creationdate>19980918</creationdate><title>The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats</title><author>de Mateos-Verchere, Juana Garcia ; Leprince, Jérôme ; Tonon, Marie-Christine ; Vaudry, Hubert ; Costentin, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-b85c96f8e53c655d4e2c953537c52f30261a49ef3d066799083f0d04f649684e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Apomorphine</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>Carrier Proteins - pharmacology</topic><topic>Cell Behavior</topic><topic>Cellular Biology</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Chemical Sciences</topic><topic>Diazepam</topic><topic>Diazepam Binding Inhibitor</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endozepine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicinal Chemistry</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Neuropeptides</topic><topic>Neuropeptides - administration & dosage</topic><topic>Neuropeptides - pharmacology</topic><topic>ODN (Octadecaneuropeptide)</topic><topic>Penile Erection</topic><topic>Penile Erection - drug effects</topic><topic>Peptide Fragments</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology</topic><topic>Pilocarpine</topic><topic>Pilocarpine - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Yawning</topic><topic>Yawning - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Mateos-Verchere, Juana Garcia</creatorcontrib><creatorcontrib>Leprince, Jérôme</creatorcontrib><creatorcontrib>Tonon, Marie-Christine</creatorcontrib><creatorcontrib>Vaudry, Hubert</creatorcontrib><creatorcontrib>Costentin, Jean</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Mateos-Verchere, Juana Garcia</au><au>Leprince, Jérôme</au><au>Tonon, Marie-Christine</au><au>Vaudry, Hubert</au><au>Costentin, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1998-09-18</date><risdate>1998</risdate><volume>357</volume><issue>2</issue><spage>121</spage><epage>126</epage><pages>121-126</pages><issn>0014-2999</issn><issn>1879-0712</issn><eissn>1879-0712</eissn><eissn>0014-2999</eissn><coden>EJPHAZ</coden><abstract>High concentrations of diazepam-binding inhibitor (DBI) have been detected in brain areas containing dopaminergic cell bodies and nerve terminals. In the present study, we have investigated the effect of a proteolytic fragment of DBI, the octadecaneuropeptide ODN, on apomorphine-induced yawning in Sprague–Dawley rats. Injection of graded doses of ODN (12.5 to 100 ng i.c.v.) caused a dose-dependent inhibition of apomorphine-induced yawning and penile erections. At a dose of 100 ng, intracerebroventricularly administered ODN was able to inhibit, during more than 3 h, the apomorphine-evoked yawning. ODN also inhibited pilocarpine-induced yawning. Apomorphine induces a bell-shaped dose-dependent effect on yawning with a maximum response at the dose of 100 μg/kg and a much lower effect at a dose of 200 μg/kg. Injection (i.c.v.) of 100 ng ODN markedly attenuated the number of yawns induced by 100 μg/kg apomorphine but partially restored the yawning behavior in rats treated with a 200 μg/kg dose of apomorphine. At doses of 0.5 or 5 mg/kg s.c., diazepam did not modify the inhibitory effect of ODN on the apomorphine-induced yawning. Taken together, the present data suggest that ODN inhibits yawning downstream dopaminergic as well as cholinergic synapses involved in yawning. In addition, the effect of ODN cannot be ascribed to an inverse agonistic activity on central-type benzodiazepine receptors.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9797027</pmid><doi>10.1016/S0014-2999(98)00570-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7814-9927</orcidid></addata></record> |
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| ispartof | European journal of pharmacology, 1998-09, Vol.357 (2), p.121-126 |
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| subjects | Animals Apomorphine Apomorphine - pharmacology Biological and medical sciences Carrier Proteins Carrier Proteins - pharmacology Cell Behavior Cellular Biology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chemical Sciences Diazepam Diazepam Binding Inhibitor Dose-Response Relationship, Drug Endozepine Fundamental and applied biological sciences. Psychology Injections, Intraventricular Life Sciences Male Medicinal Chemistry Neurobiology Neurons and Cognition Neuropeptides Neuropeptides - administration & dosage Neuropeptides - pharmacology ODN (Octadecaneuropeptide) Penile Erection Penile Erection - drug effects Peptide Fragments Pharmaceutical sciences Pharmacology Pilocarpine Pilocarpine - pharmacology Rats Rats, Sprague-Dawley Time Factors Vertebrates: nervous system and sense organs Yawning Yawning - drug effects |
| title | The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats |
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