Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation

A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and their X‐ray crystal structures are present...

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Veröffentlicht in:	ChemMedChem 2018-06, Vol.13 (12), p.1218-1229
Hauptverfasser:	Zhang, Chen, Hemmert, Catherine, Gornitzka, Heinz, Cuvillier, Olivier, Zhang, Ming, Sun, Raymond Wai‐Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties antitumor agents Bioavailability Cancer carbene ligands Cations Chemical Sciences Cisplatin Coordination chemistry Crystal structure Cytotoxicity Gold Hepatocellular carcinoma Leukemia Liver cancer nitrogen heterocycles Reactive oxygen species Reductase Thioredoxin Toxicity Tumor cell lines
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