Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function

•KCC2a isoform is expressed at the neuronal plasma membrane.•KCC2a isoform mediates chloride extrusion in cultured neurons.•SPAK differently regulates kinetic activity of KCC2a and KCC2b isoforms. The neuron-specific K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration requ...

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