FibriDerm: Interpenetrated Fibrin Scaffolds for the Construction of Human Skin Equivalents for Full Thickness Burns

The FibriDerm project aims at the development and usage of fibrin-based biomaterials, with mechanical properties adapted to new applications. These materials are elaborated from interpenetrating polymer networks in which a fibrin-based gel, obtained through enzymatic hydrolysis of fibrinogen, is associated with a synthetic polymeric network, synthesized by photochemistry. These materials are self-supported and not retractable, properties which open new fields of application for these biomaterials as mechanical support for cellular growth, and particularly relevant for tissue regeneration. The main goal of this project is to optimize already elaborated biomaterials to create Human Dermal Equivalents (HDE) solely made of cells and proteins from human origin. An intermediate material, capable of being colonized by surrounding cells and biodegradable in the long-term, will be first developed. The FibriDerm project has the ambition to lead to the development of new materials for tissue regeneration, from the initial research developments and optimizations up to pre-clinical stages, via an interdisciplinary approach. •Interpenetrating Polymer Networks create self-supported scaffolds.•These new biomaterials demonstrate excellent biocompatibility in vitro.•They do not cause inflammation after subcutaneous implantations in an animal model.•These scaffolds can be developed as a filling material or for human skin equivalent.