T Lymphocytes Potentiate Murine Dendritic Cells to Produce IL-12

IL-12 is mainly produced by CD8alpha(+) dendritic cells (DCs) and induces Th1 polarization of the immune response. We investigated the influence of lymphocytes on splenic DC (SDC) and thymic DC (TDC) development and on their IL-12 production capacity. First, CD3epsilon(-/-) mice, lacking T cells, an...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-10, Vol.169 (8), p.4237-4245
Hauptverfasser:	Rizzitelli, Alexandra, Berthier, Rolande, Collin, Veronique, Candeias, Serge M, Marche, Patrice N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cellular Biology Coculture Techniques Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Immunology Immunophenotyping Interleukin-12 - biosynthesis Interleukin-12 - genetics Interleukin-4 - physiology Life Sciences Lymphopenia - genetics Lymphopenia - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Receptor-CD3 Complex, Antigen, T-Cell - deficiency Receptor-CD3 Complex, Antigen, T-Cell - genetics RNA, Messenger - biosynthesis Spleen - cytology Spleen - immunology Spleen - metabolism Spleen - pathology T-Lymphocyte Subsets - immunology Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism Thymus Gland - pathology
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